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Clenpiq: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
10 mg/175 mL, 3.5 g/175 mL, 12 g/175 mL
Drug class:
Active ingredients:
Similar drugs:

Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Clenpiq

What is the most important information I should know about CLENPIQ?

CLENPIQ and other bowel preparations can cause serious side effects, including:

  • Serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood. These changes can cause:

    • abnormal heartbeats that can cause death.
    • seizures. This can happen even if you have never had a seizure.
    • kidney problems.
    • fainting.

Your chance of having fluid loss and changes in blood salts with CLENPIQ is higher if you:

  • have heart problems
  • have kidney problems
  • take water pills or non-steroidal anti-inflammatory drugs (NSAIDS)

Tell your healthcare provider right away if you have any of these symptoms of a loss of too much body fluid (dehydration) while taking CLENPIQ:

  • vomiting
  • urinating less often than normal
  • dizziness
  • headache

See "What are the possible side effects of CLENPIQ?" for more information about side effects.

What is CLENPIQ?

CLENPIQ is a prescription medicine used by adults and children 9 years of age and older to clean the colon before a colonoscopy. CLENPIQ cleans your colon by causing you to have diarrhea. Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy.

It is not known if CLENPIQ is safe and effective in children under 9 years of age.

Do not take CLENPIQ if your healthcare provider has told you that you have:

  • serious kidney problems.
  • a blockage in your intestine (bowel obstruction).
  • an opening in the wall of your stomach or intestines (bowel perforation).
  • a very dilated intestine (toxic megacolon).
  • problems with the emptying of food and fluid from your stomach (gastric retention).
  • an allergy to any of the ingredients in CLENPIQ. See the end of this leaflet for a complete list of ingredients in CLENPIQ.

Before taking CLENPIQ, tell your healthcare provider about all of your medical conditions, including if you:

  • have problems with serious loss of body fluid (dehydration) and changes in blood salts (electrolytes).
  • have a history of seizures or take medicines for seizures.
  • history of fainting.
  • are withdrawing from drinking alcohol or from taking benzodiazepines.
  • have low blood salt (sodium) level.
  • have kidney problems or take medicines for kidney problems.
  • have heart problems.
  • have stomach or bowel problems including ulcerative colitis.
  • have problems with swallowing or gastric reflux.
  • are pregnant. It is not known if CLENPIQ will harm your unborn baby. Talk to your provider if you are pregnant.

  • are breastfeeding or plan to breastfeed. It is not known if CLENPIQ passes into your breast milk. You and your healthcare provider should decide if you will take CLENPIQ while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

CLENPIQ may affect how other medicines work. Medicines taken by mouth may not be absorbed properly when taken within 1 hour before the start of CLENPIQ.

Especially tell your healthcare provider if you take:

  • medicines for blood pressure or heart problems.
  • medicines for kidney problems.
  • medicines for seizures.
  • water pills (diuretics).
  • nonsteroidal anti-inflammatory medicines (pain medicines).
  • medicines for depression or mental health problems.
  • laxatives. Do not take other laxatives while taking CLENPIQ.

The following medicines should be taken at least 2 hours before starting CLENPIQ and not less than 6 hours after taking CLENPIQ:

  • tetracycline
  • fluoroquinolone antibiotics
  • iron
  • digoxin (Lanoxin)
  • chlorpromazine
  • penicillamine (Cuprimine, Depen)

Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure if you are taking the medicines listed above.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take CLENPIQ?

See the Instructions for Use for dosing instructions. You must read, understand, and follow these instructions to take CLENPIQ the right way.

  • Take CLENPIQ exactly as your healthcare provider tells you to take it.
  • CLENPIQ comes ready to drink and does not need to be mixed with anything else before you take your dose of medicine.
  • CLENPIQ is a clear liquid that may have particles.
  • 1 bottle of CLENPIQ equals 1 dose. Two separate doses of CLENPIQ are required for complete colonoscopy preparation.
  • CLENPIQ is taken using the Split-Dose method. See the instructions for use for more information.

  • All people taking CLENPIQ should follow these general instructions starting 1 day before your colonoscopy:

    • only drink clear liquids all day and the next day until 2 hours before your colonoscopy. Stop drinking all fluids at least 2 hours before the colonoscopy.
    • after taking CLENPIQ if you have any bloating or feeling like your stomach is upset, wait to take your second dose until your stomach feels better.
  • If you need to take any other medicines by mouth (oral), take those medicines at least 1 hour before starting each dose of CLENPIQ.

  • While taking CLENPIQ, do not:

    • take any other laxatives.
    • eat solid foods, dairy such as milk, or alcohol while taking CLENPIQ and until after your colonoscopy.
    • eat or drink anything colored red or purple.

Contact your healthcare provider right away if after taking CLENPIQ you have severe vomiting, signs of dehydration, changes in consciousness such as feeling confused, delirious or fainting (loss of consciousness) or seizures after taking CLENPIQ.

What are the possible side effects of CLENPIQ?

CLENPIQ can cause serious side effects, including:

See "What is the most important information I should know about CLENPIQ"?

  • Changes in certain blood tests. Your healthcare provider may do blood tests after you take CLENPIQ to check your blood for changes.
  • Tell your healthcare provider if you have any symptoms of too much fluid loss, including:
  • vomiting
  • stomach area (abdominal) cramping
  • seizures
  • nausea
  • urinate less than usual
  • fainting
  • bloating
  • trouble drinking clear liquids
  • heart problems
  • dizziness
  • troubles swallowing
  • Ulcers of the bowel or bowel problems (ischemic colitis). Tell your healthcare provider right away if you have severe stomach-area (abdominal) pain or rectal bleeding.

The most common side effects of CLENPIQ in adults include:

  • nausea
  • headache
  • high magnesium levels in your blood
  • stomach area (abdominal) pain
  • dehydration or dizziness

The most common side effects of CLENPIQ in children 9 to 16 years of age include:

  • nausea
  • vomiting
  • stomach area (abdominal) pain

These are not all the possible side effects of CLENPIQ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store CLENPIQ?

  • Store CLENPIQ at room temperature, between 68° to 77°F (20° to 25°C).
  • Do not put CLENPIQ in the refrigerator or freezer.

Keep CLENPIQ and all medicines out of the reach of children.

General information about the safe and effective use of CLENPIQ.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use CLENPIQ for a condition for which it was not prescribed. Do not give CLENPIQ to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about CLENPIQ that is written for health professionals.

What are the ingredients in CLENPIQ?

CLENPIQ comes in a carton containing 2 bottles, along with an 8-ounce cup for measuring fluids for hydration.

Each bottle contains:

Active ingredients: sodium picosulfate, magnesium oxide, and anhydrous citric acid

Inactive ingredients:

acesulfame potassium, cranberry flavor, disodium edetate, malic acid, sodium benzoate, sodium hydroxide, sodium metabisulfite, sucralose, and water. The cranberry flavor contains glyceryl triacetate (triacetin), maltodextrin, and sodium octenyl succinated starch.

Manufactured for: Ferring Pharmaceuticals Inc.

Parsippany, NJ 07054, USA

For more information, go to www.CLENPIQ.com or call 1-888-337-7464.

Instructions for Use

CLENPIQ® (CLEN-pik)

(sodium picosulfate, magnesium oxide, and anhydrous citric acid)

oral solution

NOTE: Do not refrigerate or freeze CLENPIQ. CLENPIQ is ready to drink and does not need to be mixed with anything. CLENPIQ is a clear liquid that may have particles.

READ BEFORE Taking CLENPIQ

If you have questions before you start CLENPIQ, talk to your healthcare provider.

Take CLENPIQ using the Split-Dose method. This means you will take 2 separate doses. Each bottle is 1 dose and has the same ingredients. You can drink either bottle first.

  • Drink the first bottle the evening before your colonoscopy.
  • Drink the second bottle the morning of your colonoscopy.

Start a clear-liquid diet the day before your colonoscopy. Do not eat any solid foods. Drink a variety of clear liquids. Clear liquids should include balanced electrolyte solution such as sports drinks (see Table 1).

  • Drink only clear liquids all day the day before your colonoscopy.
  • Drink only clear liquids the next day until 2 hours before your colonoscopy.
  • Stop drinking all liquids at least 2 hours before your colonoscopy.

You must drink enough clear liquids to keep hydrated.

  • Drink FIVE or more 8-ounce cups of clear liquids after the first dose.
  • Drink FOUR or more 8-ounce cups of clear liquids after the second dose.

IMPORTANT: You can drink the clear liquids in Table 1.

TABLE 1: List of liquids for the clear-liquid diet

  • Water, plain or flavored. Do not drink only water.
  • Black coffee or tea (no milk, cream, soy, or nondairy creamer)
  • Sports drinks (not red or purple)
  • Plain jello (not red or purple)
  • Clear broth or bouillon
  • Clear juices without pulp (such as apple juice or white grape juice)
  • Ginger ale and other sodas (not red or purple)
  • Frozen juice bars (not red or purple)

IMPORTANT: Do NOT eat or drink the items in Table 2 starting from the day before your colonoscopy.

TABLE 2: List of foods and drinks to avoid while you are on the clear-liquid diet

  • no solid foods
  • no alcohol
  • no dairy or non-dairy types of milk or cream
  • no soy milk or drinks
  • no juices with pulp
  • no red or purple drinks
  • no red or purple jello
  • no other liquids that you cannot see through

SPLIT-DOSE INSTRUCTIONS

DOSE 1

In the evening the day before your colonoscopy (sometime between 5:00 PM to 9:00 PM)

  • Place the first bottle on a flat surface. Push down on the cap while twisting to the left (counterclockwise).
  • Drink the entire first bottle of CLENPIQ. Drink CLENPIQ right from the bottle.
  • Use the cup provided to drink five or more 8-ounce (oz) cups of clear liquids over the next 5 hours.

IMPORTANT: See Table 1 for a list of clear liquids you can drink.

If you have any bloating or upset stomach after drinking CLENPIQ, wait until your stomach feels better before taking your second dose.

DOSE 2

In the morning of your colonoscopy (about 5 hours before your colonoscopy)

  • Place the second bottle on a flat surface. Push down on the cap while twisting to the left (counterclockwise).
  • Drink the entire second bottle of CLENPIQ. Drink CLENPIQ right from the bottle.
  • Use the cup provided to drink four or more 8 ounce (oz) cups of clear liquids. You can continue to drink clear liquids up to 2 hours before the colonoscopy.

Do not eat solid food. Drink only clear liquids. Do not drink only plain water (see Table 1).

IMPORTANT: See Table 1 for a list of clear liquids you can drink.

Stop drinking clear liquids 2 hours before your colonoscopy, or as advised by your healthcare provider.

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Ferring Pharmaceuticals Inc.

Parsippany, NJ 07054, USA

Revised 08/2023

2009010037

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 209589 · View the label on DailyMed

Revision date stated in the text: August 2023

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Clenpiq

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Anti-coagulant, Calculi Dissolution Agent, Osmotic Laxative, Stimulant Laxative
Active ingredients Sodium picosulfate 10 mg/175 mL, Magnesium oxide 3.5 g/175 mL, Anhydrous citric acid 12 g/175 mL
Dosage form Liquid
Route Oral
Marketing status listed in the FDA NDC Directory
Company (applicant) FERRING PHARMS INC
FDA approval NDA 209589New Drug Application (NDA) Approved November 28, 2017
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
10 mg/175 mL, 3.5 g/175 mL, 12 g/175 mL – 175 ml in 1 bottle / 2 in 1 carton NDC 55566-6800-0
10 mg/175 mL, 3.5 g/175 mL, 12 g/175 mL – 175 ml in 1 bottle / 2 in 1 carton NDC 55566-6800-0

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.