Patient information: uses, side effects, how to take - Polyethylene Glycol 3350, Sodium Sulfate, Sodium Chloride, Potassium Chloride, Ascorbic Acid, and Sodium Ascorbate

What is the most important information I should know about Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution and other bowel preparations can cause serious side effects, including:

Serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood. These changes can cause:
abnormal heartbeats that can cause death.
seizures. This can happen even if you have never had a seizure.
kidney problems.

Your chance of having fluid loss and changes in body salts with Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution is higher if you:

have heart problems.
have kidney problems.
take water pills (diuretics), high blood pressure medicine, or non-steroidal anti-inflammatory drugs (NSAIDs).

Tell your healthcare provider right away if you have any of these symptoms of serious loss of body fluid (dehydration) while taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution:

vomiting
urinating less often than normal
dizziness
headache

See “What are the possible side effects of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?” for more information about side effects.

What is Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution is a prescription medicine used by adults to clean the colon before a colonoscopy. Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution cleans your colon by causing you to have diarrhea (loose stools). Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy.

It is not known if Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution is safe and effective in children.

Who should not take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Do not take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution if your healthcare provider has told you that you have:

a blockage in your intestine (bowel obstruction).
an opening in the wall of your stomach or intestine (bowel perforation).
problems with food and fluid emptying from your stomach (gastric retention).
a problem with food moving too slowly through your intestines (ileus).
a very dilated intestine (toxic megacolon).
an allergy to any of the ingredients in Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution. See the end of this Medication Guide for a complete list of ingredients in Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.

What should I tell my healthcare provider before taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Before taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution, tell your healthcare provider about all of your medical conditions, including if you:

have problems with serious loss of body fluid (dehydration) and changes in blood salts (electrolytes).
have heart problems.
have seizures or take medicines for seizures.
have kidney problems or take medicines for kidney problems.
have stomach or bowel problems, including ulcerative colitis.
have problems with swallowing, gastric reflux, or if you inhale food or fluid into your lungs when eating or drinking (aspirate).
have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency that destroys red blood cells.
are withdrawing from alcohol or benzodiazepines.
have phenylketonuria (PKU). Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution contains phenylalanine.
are allergic to any of the ingredients in Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
are pregnant or plan to become pregnant. It is not known if Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution will harm your unborn baby. Talk to your healthcare provider if you are pregnant.
are breastfeeding or plan to breastfeed. It is not known if Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution passes into your breast milk. You and your healthcare provider should decide if you will take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution may affect how other medicines work. Do not take medicines by mouth 1 hour before or after starting each dose of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.

Especially tell your healthcare provider if you take:

medicines to treat a blood salt (electrolyte) imbalance.
medicines for blood pressure or heart problems.
medicines for seizures (antiepileptics).
medicines for kidney problems.
water pills (diuretics).
non-steroidal anti-inflammatory drugs (NSAIDs).
laxatives. Do not take other laxatives while taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
medicines for depression or other mental health problems.
starch-based thickeners. For people who have trouble swallowing, do not mix Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution with starch-based thickeners.

Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure if you are taking any of the medicines listed above.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

See the Instructions for Use for dosing instructions. You must read, understand, and follow these instructions to take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution the right way.

Take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you to take the Two-Day Split-Dosing regimen option or the One-Day Evening Only Dosing regimen option.
On the day before the procedure, you can have breakfast, followed by a light lunch (no solid foods), and dinner of clear soup with or without plain yogurt, or plain yogurt only. You must finish dinner at least 1 hour before the start of the first Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution dose.
Drink only clear liquids before, during, and after you take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution, until 2 hours before your colonoscopy to help prevent fluid loss (dehydration).
Do not eat solid food while taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution until after your colonoscopy.
Do not eat or drink alcohol, milk, anything colored red or purple or any other foods with pulp.
It is important for you to drink the additional amount of clear liquids listed in the Instructions for Use.
You may have stomach-area (abdomen) bloating after your first dose of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
- If you have severe stomach-area (abdomen) discomfort or bloating, stop drinking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution for a short time or wait a longer time between each dose of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution until your stomach-area symptoms improve. If your stomach-area discomfort or bloating continues, tell your healthcare provider.
If you take too much Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution, call your healthcare provider.

What are the possible side effects of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution can cause serious side effects, including:

Changes in certain blood tests. Your healthcare provider may do blood tests after you take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution to check your blood for changes. Tell your healthcare provider if you have any symptoms of too much fluid loss, including:
- vomiting
- heart problems
- seizures
- dizziness
- kidney problems
- dry mouth
- feel faint, weak or lightheaded especially when you stand up (orthostatic hypotension)
Ulcers of the bowel or bowel problems (ischemic colitis). Tell your healthcare provider right away if you have severe stomach-area (abdomen) pain or rectal bleeding.
Serious allergic reactions. Symptoms of a serious allergic reaction may include:
- skin rash
- raised red patches on your skin (hives)
- kidney problems
- swelling of the face, lips, tongue and throat
- itching

The most common side effects of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution include:

anal discomfort
sleep problems
vomiting
thirst
chills
indigestion
nausea
hunger
dizziness
stomach-area (abdomen pain or bloating) discomfort

These are not all the possible side effects of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Store Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution that has not been mixed with water at room temperature, between 68°F to 77°F (20°C to 25°C).
Store Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution that has been mixed with water in an upright position in the refrigerator.
Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution should be taken within 24 hours after it has been mixed with water.

Keep Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution and all medicines out of the reach of children.

General information about the safe and effective use of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution for a condition for which it was not prescribed. Do not give Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution to other people, even if they are going to have the same procedure you are. It may harm them.

This Medication Guide summarizes the most important information about Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

For more information, call 1-800-321-4576.

What are the ingredients in Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution?

Active ingredients:

Pouch A: polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, potassium chloride.

Pouch B: ascorbic acid and sodium ascorbate.

Inactive ingredients:

Pouch A: aspartame, acesulfame potassium, and lemon flavoring including citral, lime oil, maltodextrin, acacia gum, vitamin E, and other natural flavoring agents.

Distributed by:

Oceanside Pharmaceuticals, a division of

Bausch Health US, LLC

Bridgewater, NJ 08807 USA

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Revised: October 2025

9676405 70015788-02

Instructions for Use

POLYETHYLENE GLYCOL-3350, Electrolytes, and Ascorbate for Oral Solution(polyethylene glycol 3350,
sodium sulfate, sodium chloride, potassium chloride,
sodium ascorbate, and ascorbic acid for oral solution)
There are two different options for taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution. Your healthcare provider will tell you to take the Two-Day Split-Dosing Regimen option or the One-Day Evening Only Dosing Regimen option.

Important Information on Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution:

You must drink all of the Dose 1 and Dose 2 of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution with either dosing regimen option. Make sure you finish Dose 2 at least 2 hours before your colonoscopy.
After completing Dose 2, it is important that you drink additional clear liquids (including water), but you must stop drinking all liquids at least 2 hours before your colonoscopy.
Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution is lemon flavored containing citral, lime oil, maltodextrin, acacia gum, vitamin E, and other natural flavoring agents.
Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution must be mixed with water. Do not add any other ingredients to Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
Do not mix Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution with starch-based thickeners.
After you start taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution, you can only drink clear liquids (no solid foods) until after your colonoscopy. Examples of clear liquids include:
- water
- clear fruit juices without pulp including apple, white grape, or white cranberry
- strained limeade or lemonade
- coffee or tea (do not use any dairy or non-dairy creamer)
- clear broth
- clear soda
- gelatin (without added fruit or topping, no red or purple)
- popsicles (without pieces of fruit or pulp, no red or purple)
Drink plenty of clear liquids before, during, and after you take Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution, up until 2 hours before your colonoscopy, to help prevent fluid loss (dehydration).
Do not eat or drink anything within 2 hours before your colonoscopy.
Do not eat or drink alcohol, milk, anything colored red or purple or containing pulp.
Do not take other laxatives while taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
Do not take any medicines by mouth (oral) within 1 hour before or after starting each dose of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
Do not eat any solid food while taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution until after your colonoscopy.

To take each dose of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution, you will need:

Mixing Container that comes with Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution
One Pouch A
One Pouch B
Lukewarm water
For the Two-Day Split-Dosing Regimen:
On the day before the colonoscopy you can eat breakfast followed by a light lunch (no solid foods). For dinner you may have a clear soup with or without plain yogurt, or plain yogurt only.
You must finish eating at least 1 hour before you start taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
You must take the first dose between 10 to 12 hours before the second dose. The second dose must be taken at least 3 ½ hours before the colonoscopy.
After you start taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution you can only drink clear liquids.
For the One-Day Evening Only Dosing Regimen:
On the day before the colonoscopy you can eat breakfast followed by a light lunch. For dinner you may have a clear soup with or without plain yogurt, or plain yogurt only.
You must finish eating at least 1 hour before you start taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.
You must take the first dose 3 ½ hours before bedtime the evening before the colonoscopy.
After you start taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution you can only drink clear liquids.
Take the second dose 1 ½ hours after starting Dose 1.

Two-Day Split-Dosing Regimen Dosing Instructions

Dose 1 – Take this dose the evening before your colonoscopy (10 to 12 hours before Dose 2):

Step 1: Empty the contents of one Pouch A and one Pouch B into the Mixing Container that comes with Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.

Step 2: Add lukewarm water to the Fill Line on the Mixing Container. You will need at least 32 ounces.

Step 3: Mix to completely dissolve the medicine from Pouch A and Pouch B into the lukewarm water. To mix the solution, stir the medicine in the Mixing Container with a spoon, or close the lid and shake.

Step 4: Drink one 8 oz. (ounce) glass of the solution every 15 minutes. Be sure to drink all of the solution in the Mixing Container. It should take about 1 hour to drink all the liquid.

If you feel like you have severe stomach pain or discomfort you can stop taking Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution for a short period of time and then continue taking it or you can take smaller sips of Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution so that you space out your dose longer than 1 hour. If you still have severe stomach pain, call your healthcare provider.

Step 5: Refill the Mixing Container with 16 oz. (at least halfway to Fill Line and enough for two 8 oz. glasses) of a clear liquid and drink all of this liquid before you go to bed.

Dose 2 – Take this dose the next morning on the day of your colonoscopy (start at least 3 ½ hours before your colonoscopy):
Step 1: Repeat steps 1 through 4 from Dose 1 of the Split-Dose (2-Day) instructions.

Step 2: Fill the Mixing Container with 16 oz. (at least halfway to Fill Line and enough for two 8 oz. glasses) of a clear liquid and drink all of this liquid at least 2 hours before your colonoscopy.

Step 3: Drink only clear liquids up to 2 hours before your colonoscopy or as prescribed by your healthcare provider. Then stop drinking liquids until after your colonoscopy.

One-Day Evening Only Dosing Regimen Instructions

Dose 1 (take at least 3 ½ hours before bedtime the evening before your colonoscopy):

Step 1: Empty the contents of one Pouch A and one Pouch B into the Mixing Container that comes with Polyethylene Glycol-3350, Electrolytes, and Ascorbate for Oral Solution.

Step 2: Add lukewarm water to the Fill Line on the Mixing Container. You will need at least 32 ounces.

Step 3: Mix to completely dissolve the medicine from Pouch A and Pouch B into the lukewarm water. To mix the solution, stir the medicine in the Mixing Container with a spoon, or close the lid and shake.

Step 4: Drink one 8 oz. (ounce) glass of the solution every 15 minutes. Be sure to drink all of the solution in the Mixing Container. It should take about 1 hour to drink all the liquid.

Dose 2 (take about 1 ½ hours after starting Dose 1):

Step 1: Repeat Steps 1 through 4 from Dose 1 of the Evening Only (1-Day) instructions.
Step 2: After you complete steps 1 through 4, fill the Mixing Container again to the Fill Line with clear liquid and drink all of this liquid before you go to bed.

Step 3: Drink only clear liquids up to 2 hours before your colonoscopy or as prescribed by your healthcare provider. Then stop drinking liquids until after your colonoscopy.

This Instructions for Use has been approved by the U.S. Food and Drug Administration.