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Cinvanti (Aprepitant): Uses, Side Effects and Dosage

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Facts
Status:
Prescription (Rx)
Strength:
130 mg/18 mL
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Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Cinvanti

What is CINVANTI?

CINVANTI is a prescription medicine used with other medicines that treat nausea and vomiting in adults to prevent nausea and vomiting caused by certain anti-cancer (chemotherapy) medicines.

  • CINVANTI is not used to treat nausea and vomiting that you already have.
  • It is not known if CINVANTI is safe and effective in children.

Do not receive CINVANTI if you:

  • are allergic to aprepitant, or any of the ingredients in CINVANTI. See the end of this leaflet for a complete list of the ingredients in CINVANTI.
  • are taking pimozide (ORAP).

Before receiving CINVANTI, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.

  • are pregnant or plan to become pregnant. CINVANTI may harm your unborn baby.

    • Women who use birth control medicines containing hormones to prevent pregnancy (birth control pills, skin patches, implants, and certain IUDs) should also use a backup method of birth control that does not contain hormones, such as condoms and spermicides, during treatment with CINVANTI and for 1 month after receiving the last dose of CINVANTI.
  • are breastfeeding or plan to breastfeed. It is not known if CINVANTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive CINVANTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the- counter medicines, vitamins, and herbal supplements.

CINVANTI may affect the way other medicines work, and other medicines may affect the way CINVANTI works, causing serious side effects.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

How will I receive CINVANTI?

  • CINVANTI is given on Day 1. It will be given to you by intravenous (IV) injection or infusion in your vein about 30 minutes before you start your chemotherapy treatment.
  • If you take the blood thinner medicine warfarin sodium (COUMADIN, JANTOVEN), your healthcare provider may do blood tests after you receive CINVANTI to check your blood clotting.

What are the possible side effects of CINVANTI?

CINVANTI may cause serious side effects, including:

  • Serious allergic reactions.Serious allergic reactions can happen during your CINVANTI infusion. Tell your healthcare provider or nurse right away if you get any of these symptoms during or soon after your infusion:

    • trouble breathing or swallowing, shortness of breath or wheezing
    • swelling of your eyes, face, tongue, or throat
    • flushing or redness of your face or skin
    • hives, rash, itching
    • dizziness, a rapid or weak heartbeat, or you feel faint

The most common side effects of CINVANTI include:

  • tiredness
  • diarrhea
  • low white blood cell and red blood cell counts
  • weakness
  • feeling weak or numb in your arms and legs
  • headache
  • indigestion
  • urinary tract infection
  • belching or burping
  • pain in your arms and legs

Infusion-site side effects with CINVANTI may include: pain, hardening, redness or itching at the site of infusion. Swelling (inflammation) of a vein caused by a blood clot can also happen at the infusion site. Tell your healthcare provider if you get any infusion-site side effects.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of CINVANTI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of CINVANTI.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information about CINVANTI that is written for health professionals.

What are the ingredients in CINVANTI?

Active ingredient: aprepitant

Inactive ingredients: egg lecithin, dehydrated alcohol (3.6% alcohol by volume), sodium oleate, soybean oil, sucrose, and water for injection.

Manufactured for: Heron Therapeutics, Inc., Cary, NC 27511

Patent: https://herontx.com/patents/

CINVANTI® is a registered trademark of Heron Therapeutics, Inc.

Copyright © 2017-2026 Heron Therapeutics, Inc. All rights reserved.

For more information about CINVANTI call 1-844-437-6611 or go to www.CINVANTI.com.

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 209296 · View the label on DailyMed

Revision date stated in the text: April 2026

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Cinvanti

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Substance P/Neurokinin-1 Receptor Antagonist
Active ingredient Aprepitant 130 mg/18 mL
Dosage form Injection, emulsion
Route Intravenous
Marketing status listed in the FDA NDC Directory
Company (applicant) HERON THERAPS INC
FDA approval NDA 209296New Drug Application (NDA) Approved November 9, 2017
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
130 mg/18 mL – 18 ml in 1 vial, glass / 1 in 1 carton NDC 47426-201-01

Source: FDA drug labeling via NLM DailyMed, data as of November 7, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.