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Varubi: Uses, Side Effects and Dosage

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Status:
Prescription (Rx)
Strength:
90 mg
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Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Varubi

What is VARUBI?

  • VARUBI is a prescription medicine called an “antiemetic.” VARUBI is used with other medicines in adults to help prevent nausea and vomiting that happens later with certain anti-cancer medicines (chemotherapy).
  • It is not known if VARUBI is safe and effective in children.

Do not take VARUBI if you:

  • take thioridazine or pimozide. Taking VARUBI with thioridazine or pimozide can cause serious or life-threatening heart rhythm changes.
  • are a child less than 2 years of age.

Before taking VARUBI, tell your doctor about all of your medical conditions, including if you:

  • have liver problems.

  • are pregnant or plan to become pregnant. It is not known if VARUBI will harm your unborn baby. VARUBI may affect the ability to have a child (fertility problems) in females.

  • are breastfeeding or plan to breastfeed. It is not known if VARUBI passes into your breast milk or could harm your baby. Talk to your doctor about the best way to feed your baby if you take VARUBI.

Tell your doctor about all the medicines you take or stop taking, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Keep a list of your medicines to show your doctor and pharmacist when you get a new medicine.

VARUBI and other medicines may affect each other and could cause serious side effects.

How should I take VARUBI?

  • Take VARUBI exactly as your doctor tells you to take it.
  • VARUBI is taken on Day 1 of chemotherapy. Take 2 VARUBI tablets by mouth within 2 hours before you receive your anti-cancer medicine (chemotherapy).

  • VARUBI can be taken with or without food.

  • Do not take VARUBI more than 1 time every 14 days.
  • If you take too much VARUBI, call your doctor or go to the nearest hospital emergency room right away.

What are the possible side effects of VARUBI?

VARUBI may cause serious side effects, including:

  • Change in the level of some medicines in your blood. Serious or life-threatening reactions, including heart rhythm changes, may occur if VARUBI is used with certain other medicines. You should not take VARUBI if you take thioridazine or pimozide.

The most common side effects of VARUBI in people who take VARUBI and receive Cisplatin chemotherapy medicine include: low white blood cell count, hiccups, and stomach (abdominal) pain.

The most common side effects of VARUBI in people who take VARUBI and receive Anthracycline and Cyclophosphamide chemotherapy medicines include: decreased appetite, low white blood cell count, dizziness, indigestion, urinary tract infection, mouth sores, and low red blood cell count.

These are not all the possible side effects of VARUBI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store VARUBI?

  • VARUBI comes in a child-resistant package.
  • Store VARUBI at room temperature between 68°F to 77°F (20°C to 25°C).

Keep VARUBI and all medicines out of the reach of children.

General information about the safe and effective use of VARUBI.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use VARUBI for a condition for which it was not prescribed. Do not give VARUBI to other people, even if they have the same symptoms that you have. It may harm them. You can ask your doctor or pharmacist for information about VARUBI that is written for health professionals.

What are the ingredients in VARUBI?

Active ingredient: rolapitant

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and pregelatinized starch. The tablets are coated in non-functional blue and clear coats. The tablet coating comprises the following inactive ingredients: FD&C Blue No. 2-Indigo Carmine Lake, polyethylene glycol, polysorbate 80, polyvinyl alcohol, talc, and titanium dioxide.

Distributed by: Luria Therapeutics LLC, Pleasant Prairie, WI 53158

For more information, go to www.varubirx.com or call 1-844-334-4035.

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 206500 · View the label on DailyMed

Revision date stated in the text: August 2026

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Varubi

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Substance P/Neurokinin-1 Receptor Antagonist
Active ingredient Rolapitant hydrochloride 90 mg
Dosage form Tablet
Route Oral
Marketing status listed in the FDA NDC Directory
Company (applicant) TERSERA
FDA approval NDA 206500New Drug Application (NDA) Approved September 1, 2015
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Manufacturers 2 labelers list this drug on DailyMed
Packages (NDC)
Package
90 mg – 2 in 1 blister pack NDC 87628-101-02

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.