Patient information: uses, side effects, how to take - Palonosetron
What is Palonosetron Hydrochloride Injection?
Palonosetron hydrochloride injection is a prescription medicine called an “antiemetic.”
Palonosetron hydrochloride injection is used in adults to help prevent the nausea and vomiting that happens:
- right away or later with certain anti-cancer medicines (chemotherapy)
- up to 24 hours while recovering from anesthesia after surgery
Palonosetron hydrochloride injection is used in children 1 month old to less than 17 years of age to help prevent the nausea and vomiting that happens right away with certain anti-cancer medicines (chemotherapy).
- It is not known if palonosetron hydrochloride injection is safe and effective in children less than 1 month old to help prevent nausea and vomiting after chemotherapy.
- It is not known if palonosetron hydrochloride injection is safe and effective in children for the prevention of nausea and vomiting while recovering from anesthesia after surgery.
Who should not receive Palonosetron Hydrochloride Injection?
Do not receive palonosetron hydrochloride injection if you are allergic to palonosetron hydrochloride or any of the ingredients in palonosetron hydrochloride injection. See the end of this leaflet for a complete list of ingredients in palonosetron hydrochloride injection.
What should I tell my doctor before receiving Palonosetron Hydrochloride Injection?
Before receiving palonosetron hydrochloride injection, tell your doctor about all of your medical conditions, including if you:
- have had an allergic reaction to another medicine for nausea or vomiting
are pregnant or plan to become pregnant. It is not known if palonosetron hydrochloride injection will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if palonosetron hydrochloride passes into your breast milk or if it will affect your baby or your breast milk. Talk to your doctor about the best way to feed your baby if you will receive palonosetron hydrochloride injection.
Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
Palonosetron hydrochloride injection and certain other medicines can affect each other, causing serious side effects.
How will I receive Palonosetron Hydrochloride Injection?
- Palonosetron hydrochloride injection will be given to you in your vein by intravenous (I.V.) injection.
- Palonosetron hydrochloride injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anesthesia for surgery.
What are the possible side effects of palonosetron hydrochloride injection?
Palonosetron hydrochloride injection may cause serious side effects, including:
- Serious allergic reactions,such as anaphylaxis. Get emergency medical help right away if you get any of the following symptoms.
- hives
- swollen face
- breathing trouble
- chest pain
- Serotonin Syndrome.A possible life threatening problem called serotonin syndrome can happen with medicines called 5-HT 3receptor antagonists, including palonosetron hydrochloride injection, especially when used with medicines used to treat depression and migraine headaches called serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs) and certain other medicines. Tell your doctor or nurse right away if you have any of the following symptoms of serotonin syndrome:
- agitation, seeing things that are not there (hallucinations), confusion, or coma
- fast heartbeat or unusual and frequent changes in your blood pressure
- dizziness, sweating, flushing, or fever
- tremors, stiff muscles, muscle twitching, overactive reflexes, or loss of coordination
- seizures
- nausea, vomiting, or diarrhea
The most common sideeffects in adults who receive palonosetron hydrochloride injection to help prevent nausea and vomiting that happens with certain anti-cancer medicine (chemotherapy)include: headache and constipation.
The most common sideeffects in adults who receive palonosetron hydrochloride injection to help prevent nausea and vomiting that happens while recovering from anesthesiaafter surgery include: serious or life-threatening heart rhythm changes (QT prolongation), slow heartbeat, headache, and constipation.
These are not all the possible side effects from palonosetron hydrochloride injection.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
General information about the safe and effective use of palonosetron hydrochloride injection. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your doctor or pharmacist for information about palonosetron hydrochloride injection that is written for health professionals.
What are the ingredients in Palonosetron Hydrochloride Injection?
Active ingredient:palonosetron hydrochloride
Inactive ingredients: mannitol, disodium edetate and sodium acetate trihydrate in water. Hydrochloric acid or sodium hydroxide may have been added to adjust pH.
For more information, call 1-888-375-3784.
This Patient Information has been approved by the U.S. Food and Drug Administration.
Rx Only
Mfd. By:
Dr. Reddy’s Laboratories Ltd.
Visakhapatnam 530 046 – INDIA
For BluePoint Laboratories
Revised: 06/2026