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Dihydroergotamine Nasal (Atzumi): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx) Boxed warning
Strength:
4 mg/mL
Brand names:
Drug class:
Active ingredient:
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Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Dihydroergotamine Nasal

How to use the Dihydroergotamine Mesylate Nasal Spray

  1. 1. Use available training materials.
  2. 2. Read and follow the instructions in the administration instructions which are provided with the Dihydroergotamine Mesylate Nasal Spray package before attempting to use the product.
  3. 3. If there are any questions concerning the use of your Dihydroergotamine Mesylate Nasal Spray, ask your doctor or pharmacist, or contact Bausch Health US, LLC at 1-800-321-4576.
  4. 4. Check the contents of the package:
  5. 5. 8 Nasal Spray Vials
  6. 6. 8 Nasal Sprayers
  7. 7. Administration Instructions
  8. 8. Package Insert
  9. 9.

    Assemble the sprayer:

    Assemble your nasal sprayer only when you are ready to use it.

  10. 10. Lift tab to bend back blue cover. In one piece, completely remove the blue cover and metal seal in a circular motion. Keeping the vial upright, remove rubber stopper. Set vial aside.
  11. 11. Remove plastic cover from the bottom of pump unit. Insert spray pump into vial and turn clockwise until securely fastened.
  12. 12. Using the sprayer:
  13. 13. Remove cap from spray unit. Holding the vial upright, point nasal sprayer away from face and pump 4 times before using. DO NOT PUMP MORE THAN 4 TIMES. (Although some medication will spray out, there is enough medication in each vial to allow you to prepare your nasal spray pump properly and still receive a full treatment of Dihydroergotamine Mesylate Nasal Spray.)
  14. 14. Spray once into each nostril. Do not tilt head back or sniff through your nose while spraying or immediately after.Wait 15 minutes. Spray once again into each nostril.
  15. 15. After completing these instructions:
  16. 16. Carefully dispose of the nasal spray pump with the vial.

Important Notes:

  • Once a Dihydroergotamine Mesylate Nasal Spray vial has been opened, it must be thrown away after 8 hours.

Storing Dihydroergotamine Mesylate Nasal Spray

  • Keep medication in a safe place away from children
  • Keep Dihydroergotamine Mesylate Nasal Spray away from heat and light.
  • Do not expose Dihydroergotamine Mesylate Nasal Spray to temperatures over 77°F.
  • Never refrigerate or freeze Dihydroergotamine Mesylate Nasal Spray.
  • Do not keep an opened Dihydroergotamine Mesylate Nasal Spray vial for more than 8 hours.
  • Check the expiration date printed on the vial containing medication. If the expiration date has passed, do not use it.

Answers to patients’ questions about Dihydroergotamine Mesylate Nasal Spray

What if I need help in using my Dihydroergotamine Mesylate Nasal Spray?

If you have any questions or if you need help in opening, putting together, or using Dihydroergotamine Mesylate Nasal Spray, speak to your doctor or pharmacist, or contact Bausch Health US, LLC at 1-800-321-4576.

How much medication should I use and how often?

Each vial contains one complete dose of Dihydroergotamine Mesylate Nasal Spray, which is 1 spray in each nostril, followed by an additional spray in each nostril 15 minutes later for a total of 4 sprays. Do not use more than this amount unless instructed to do so by your doctor. Dihydroergotamine Mesylate Nasal Spray is not intended for chronic daily use.

Why do I have to prime or pump the Nasal Sprayer 4 times before using?

Am I wasting the medication?

You have to prime the Nasal Sprayer 4 times to make sure that you get the proper amount of medication when you use it. Although you will see some medication spray out, there is still enough medication in each vial to allow you to prepare your sprayer properly and still receive a full dose of Dihydroergotamine Mesylate Nasal Spray.

Can I assemble the medication vial and the Nasal Sprayer so it is ready before I need to use it?

No. The brown (amber) glass vial containing your medication must remain unopened until you are ready to use it. It may not be fully effective if opened and not used within 8 hours.

Can I reuse my Dihydroergotamine Mesylate Nasal Sprayer?

No. After completing the full dose, you must carefully dispose of your Dihydroergotamine Mesylate Nasal Sprayer and the opened vial. You should use a new unit for your next migraine attack. Each Unit contains a new Nasal Sprayer, and a vial of Dihydroergotamine Mesylate Nasal Spray medication.

Can I use Dihydroergotamine Mesylate Nasal Spray if I have a stuffy nose, cold, or allergies?

Yes. Dihydroergotamine Mesylate Nasal Spray can be used if you have a stuffy nose, cold, or allergies. However, if you are taking any medications for your cold, or allergies, even those you can buy without a doctor’s prescription, speak with your doctor before using Dihydroergotamine Mesylate Nasal Spray.

Do I need to sniff the medication when I spray it in my nostril?

No, you should not sniff because Dihydroergotamine Mesylate Nasal Spray should remain in the nose so that it can be absorbed into the bloodstream through the lining of the nose.

If you have any other unanswered questions about Dihydroergotamine Mesylate Nasal Spray, consult your doctor or pharmacist.

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA AUTHORIZED GENERIC 020148 · View the label on DailyMed

Revision date stated in the text: September 2022

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Dihydroergotamine Nasal

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Boxed warning Yes – this drug has a boxed warning (also called a black box warning), the strongest warning of the FDA.
Drug class Ergotamine Derivative
Active ingredient Dihydroergotamine mesylate 4 mg/mL
Dosage form Spray
Route Nasal
Marketing status listed in the FDA NDC Directory
Company (applicant) BAUSCH
FDA approval NDA AUTHORIZED GENERIC 020148NDA authorized generic Approved December 8, 1997
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Therapeutic equivalence (TE) code ABCodes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Manufacturers 6 labelers list this drug on DailyMed
Packages (NDC)
Package
4 mg/mL – 1 ml in 1 vial / 8 in 1 kit NDC 68682-357-10

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.