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Vyepti (Eptinezumab): Uses, Side Effects and Dosage

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Facts
Status:
Prescription (Rx)
Strength:
100 mg/mL
Drug class:
Active ingredient:
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Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Vyepti

What is VYEPTI?

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

It is not known if VYEPTI is safe and effective in children.

Do not receive VYEPTI if you are allergic to eptinezumab-jjmr or any of the ingredients in VYEPTI. See the end of this Patient Information leaflet for a complete list of ingredients in VYEPTI.

Before you receive VYEPTI, tell your healthcare provider about all of your medical conditions, including if you:

  • have high blood pressure.
  • have circulation problems in your fingers and toes.

  • are pregnant or plan to become pregnant. It is not known if VYEPTI will harm your unborn baby.

    • Pregnancy Registry: There is a pregnancy registry for women who take VYEPTI. The purpose of this registry is to collect information about the health of you and your baby. You may enroll yourself by calling 1-855-810-8549 or by visiting www.vyeptipregnancyregistry.lundbeck.com. Or you may talk to your healthcare provider about how you can take part in this registry.
  • are breastfeeding or plan to breastfeed. It is not known if VYEPTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using VYEPTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive VYEPTI?

  • VYEPTI will be given by a healthcare provider in a healthcare setting.
  • VYEPTI is given by intravenous (IV) infusion in your vein.
  • VYEPTI will be given over 30 minutes every 3 months.

If you have questions about your infusion schedule, ask your healthcare provider.

What are the possible side effects of VYEPTI?

VYEPTI may cause serious side effects, including:

  • Allergic reactions. Allergic reactions can happen after receiving VYEPTI. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms of an allergic reaction:

    • rash
    • swelling of your face, lips, tongue or throat
    • trouble breathing
    • hives
    • redness in your face
  • Constipation with serious complications. Severe constipation can happen after receiving VYEPTI. In some cases, people have been hospitalized. Contact your healthcare provider if you have severe constipation or constipation is associated with symptoms such as severe or constant belly pain, vomiting, swelling of belly, or bloating.
  • High blood pressure. High blood pressure or worsening of high blood pressure can happen after receiving VYEPTI. Contact your healthcare provider if you have an increase in blood pressure.
  • Raynaud’s phenomenon. A type of circulation problem can worsen or happen after receiving VYEPTI. Raynaud’s phenomenon can lead to your fingers or toes feeling numb, cool, or painful, or changing color from pale, to blue, to red. Contact your healthcare provider if these symptoms occur.

The most common side effects of VYEPTI include:

  • stuffy nose and scratchy throat
  • allergic reactions

These are not all of the possible side effects of VYEPTI.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of VYEPTI.

Medicines are sometimes prescribed for purposes other than those listed in the Patient Information leaflet.

You can ask your pharmacist or healthcare provider for information about VYEPTI that is written for health professionals.

What are the ingredients in VYEPTI?

Active ingredient: eptinezumab-jjmr

Inactive ingredients: L-histidine, L-histidine hydrochloride monohydrate, polysorbate 80, sorbitol, and Water for Injection.

The vial stopper is not made with natural rubber latex.

Manufactured by: Lundbeck Seattle BioPharmaceuticals, Inc., 11804 North Creek Parkway South, Bothell, WA 98011

US License Number: 2097

Vyepti is a registered trademark of Lundbeck Seattle BioPharmaceuticals, Inc.

For more information, call 1-833-4-VYEPTI (833-489-3784) or go to www.Vyepti.com

This Patient Information has been approved by the U.S. Food and Drug Administration. Revised: 06/2026

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: BLA 761119 · View the label on DailyMed

Revision date stated in the text: June 2026

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Vyepti

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Calcitonin Gene-related Peptide Antagonist
Active ingredient Eptinezumab 100 mg/mL
Dosage form Injection
Route Intravenous
Marketing status listed in the FDA NDC Directory
Company (applicant) Lundbeck Seattle BioPharmaceuticals, Inc.
FDA approval BLA 761119Biologics License Application (BLA) Approved February 21, 2020
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
100 mg/mL – 1 ml in 1 vial, single-dose / 1 in 1 carton NDC 67386-130-51
100 mg/mL – 1 ml in 1 vial, single-dose / 1 in 1 carton NDC 67386-130-91

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.