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Uptravi (Selexipag): Uses, Side Effects and Dosage

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Prescription (Rx)
Strength:
200 mcg, 1800 mcg/10 mL, 100 mcg, 150 mcg, 400 mcg, 600 mcg, 800 mcg, 1000 mcg, 1200 mcg, 1400 mcg, 1600 mcg
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Active ingredient:
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Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Uptravi

What is UPTRAVI?

  • UPTRAVI is a prescription medicine used to treat adults and children 2 years of age and older with pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs.
  • UPTRAVI can help slow down the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI is safe and effective in children younger than 2 years of age.

Do not take UPTRAVI if you or your child:

  • are allergic to selexipag or any of the other ingredients in UPTRAVI (see the end of the Patient Information leaflet for a complete list of ingredients).
  • take gemfibrozil because this medicine may affect how UPTRAVI works and cause side effects.

Before you or your child take UPTRAVI, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.
  • have narrowing of the pulmonary veins, a condition called pulmonary veno-occlusive disease.

  • are pregnant or plan to become pregnant. It is not known if UPTRAVI will harm your unborn baby.

  • are breastfeeding or plan to breastfeed. It is not known if UPTRAVI passes into your breast milk. You and your healthcare provider should decide if you will take UPTRAVI or breastfeed. You should not do both.

Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. UPTRAVI and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider.

How should you or your child take UPTRAVI?

UPTRAVI tablets

  • Take or give UPTRAVI exactly as your healthcare provider tells you to take it. Do not stop taking UPTRAVI unless your healthcare provider tells you to stop.
  • Your child's healthcare provider will prescribe an UPTRAVI starting dose based on your child's body weight.
  • Your healthcare provider will slowly increase your or your child's dose to find the dose of UPTRAVI that is right.
  • If you or your child have side effects, your healthcare provider may tell you to change the dose of UPTRAVI.

  • UPTRAVI can be taken with or without food. Taking UPTRAVI with food may help you or your child tolerate UPTRAVI better.

  • UPTRAVI is usually taken 2 times each day.
  • Swallow UPTRAVI tablets whole. Do not split or crush UPTRAVI tablets.

  • If you or your child cannot swallow the tablets:

    • Dissolve (disperse) the 100 mcg or 150 mcg tablet(s) in apple or orange juice. Do not disperse the tablet(s) in water or milk.

      • Place the required number of tablet(s) for the prescribed dose in a cup. Do not crush or split the tablet(s).
      • Add 1 or 2 teaspoons of apple or orange juice to the prescribed number of tablets.
      • Wait for 5 minutes, then stir the juice and the tablet(s) until the tablets are dispersed.
      • Take or give the mixture right away.

    UPTRAVI tablets can also be given with soft foods as follows:

    • Cover the prescribed number of 100 mcg or 150 mcg tablets with a small amount of soft food, such as yogurt, applesauce or mashed banana.
    • Take or give the mixture right away. Make sure no remaining medicine is left in the container by adding more soft food and take or give the mixture right away.

    Do not store UPTRAVI tablets that are already mixed with juice or soft food for later use.

  • If you or your child miss a dose of UPTRAVI, take it as soon as you remember. If the next scheduled dose is due within 6 hours, skip the missed dose. Take the next dose at the regular time.
  • If you or your child miss 3 or more days of UPTRAVI, call your healthcare provider to see if the dose needs to be changed.
  • If you or your child take too much UPTRAVI, call your healthcare provider or go to the nearest hospital emergency room right away.

UPTRAVI given by intravenous (IV) injection

  • Your healthcare provider will give you UPTRAVI into your vein through an intravenous line.
  • Your healthcare provider will decide how much UPTRAVI for injection you will receive each day, based on your current dose of UPTRAVI tablets.

What are the possible side effects of UPTRAVI?

The most common side effects of UPTRAVI in adults and children include:

  • headache
  • diarrhea
  • jaw pain
  • nausea
  • muscle pain
  • vomiting
  • pain in arms or legs
  • flushing

Additional common side effects of UPTRAVI in adults include:

  • pain in joints
  • rash
  • low red blood cell count
  • decreased appetite
  • redness, pain, or swelling at the injection site

Additional common side effect in children includes stomach (abdominal) pain.

These are not all of the possible side effects of UPTRAVI.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store UPTRAVI tablets?

  • Store UPTRAVI tablets at room temperature between 68 °F and 77 °F (20 °C and 25 °C).
  • Store UPTRAVI 100 mcg or 150 mcg tablets in the original package to protect from moisture.

Keep UPTRAVI and all medicines out of the reach of children.

General information about the safe and effective use of UPTRAVI

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use UPTRAVI for a condition for which it was not prescribed. Do not give UPTRAVI to other people, even if they have the same symptoms that you or your child have. It may harm them. You can ask your healthcare provider or pharmacist for information about UPTRAVI that is written for health professionals.

What are the ingredients in UPTRAVI?

UPTRAVI tablets

Active ingredient: selexipag

Inactive ingredients: corn starch, D-mannitol, hydroxypropyl cellulose, low substituted hydroxypropyl cellulose, and magnesium stearate. The tablets are film coated with a coating material containing carnauba wax, hypromellose, propylene glycol, titanium dioxide, along with mixtures of iron oxide black, iron oxide red, and/or iron oxide yellow. The coating material of the 100 mcg and 150 mcg tablets also contains talc.

UPTRAVI for injection

Active ingredient: selexipag

Inactive ingredients: glycine, phosphoric acid, polysorbate 20, and sodium hydroxide.

Manufactured for:

Actelion Pharmaceuticals US, Inc.

Titusville, NJ 08560, USA

For patent information: www.janssenpatents.com

© Johnson & Johnson and its affiliates, 2015 – 2021, 2026.

For more information, contact Actelion at 1-800-526-7736 or go to www.UPTRAVI.com.

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 207947 · View the label on DailyMed

Revision date stated in the text: May 2026

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Uptravi

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Prostacyclin Receptor Agonist
Active ingredient Selexipag
Dosage form Tablet, coated, Injection, powder, for solution, Tablet, film coated, Kit
Route Oral
Marketing status listed in the FDA NDC Directory
Company (applicant) ACTELION
FDA approval NDA 207947New Drug Application (NDA) Approved December 21, 2015
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Therapeutic equivalence (TE) code ABCodes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
200 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-602-06
200 mcg – 140 in 1 bottle / 1 in 1 carton NDC 66215-602-14
1800 mcg/10 mL – 10 ml in 1 vial, single-dose / 1 in 1 carton NDC 66215-718-01
100 mcg – 140 in 1 bottle / 1 in 1 carton NDC 66215-910-14
150 mcg – 140 in 1 bottle / 1 in 1 carton NDC 66215-915-14
400 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-604-06
600 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-606-06
800 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-608-06
1000 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-610-06
1200 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-612-06
1400 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-614-06
1600 mcg – 60 in 1 bottle / 1 in 1 carton NDC 66215-616-06
Show more packages (1)+
200 mcg, 800 mcg – 1 in 1 carton NDC 66215-628-20

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.