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Pliaglis: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
70 mg/g, 70 mg/g
Drug class:
Active ingredients:
Similar drugs:

Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Pliaglis

Instructions for Use

Pliaglis® [Ply-uh-gliss]

(lidocaine and tetracaine) Cream

Read and follow this Instructions for Use before applying PLIAGLIS Cream.

PLIAGLIS Cream is a prescription medicine used on adults to numb your skin to reduce the pain associated with medical procedures on the skin. After PLIAGLIS Cream is applied to your skin, it will form a film (or mask) that is removed before your procedure.

Important Information:

Keep PLIAGLIS Cream out of the reach of children and away from pets.

  • Do not apply PLIAGLIS Cream to skin that is broken, cut, scratched, irritated (red) or has a rash.
  • Do not apply PLIAGLIS to a procedure site after the procedure has been performed.
  • Do not use more PLIAGLIS Cream than prescribed.
  • Do not leave PLIAGLIS Cream on your skin for longer than 120 minutes (2 hours).
  • Avoid getting PLIAGLIS Cream in your eyes or on your lips. If contact occurs, rinse immediately with water and if irritation occurs, seek medical advice.
  • Always wash your hands after handling PLIAGLIS Cream.
  • Do not cover PLIAGLIS Cream with waterproof (occlusive) dressing or overdosage may occur.
  • Store PLIAGLIS Cream in the refrigerator. PLIAGLIS Cream may be stored at room temperature for up to 3 months

Step 1: Check the skin where the cream will be applied.

Check the skin area to be treated to make sure the skin is intact.

Read and follow Important Information notices in grey box above.

Step 2: Estimate the amount of PLIAGLIS Cream to apply.

Apply PLIAGLIS Cream exactly as your healthcare provider tells you to. Your healthcare provider will tell you the area to be treated, when to apply the cream, and how long to leave it on your skin.

Estimate the area of the skin to be treated and the amount of PLIAGLIS Cream to apply using the table below and the ruler on the applicator included in the carton. Break the cream length into smaller segments that fit inside the treatment area.

Approximate size of area to be treatedLength of cream (inches) based on 30-gram tube
1 inch × 1 inch¾ inch
2 inches × 2 inches3 inches
2 inches × 3 inches (size of a credit card)5 inches
3 inches × 5 inches (size of a 3 inch × 5 inch photo)12 inches (½ tube)
4 inches × 6 inches (size of a 4 inch × 6 inch postcard)18 inches (⅔ tube)
Half of your face1 tube
6 inches × 8 inches (size of two 4 inch × 6 inch postcards)1½ tubes
Full face2 tubes

Step 3: Open the tube and apply PLIAGLIS Cream to your skin.

Open the tube by pushing down the cap while turning counter-clockwise.

Using the table above and the ruler on the applicator included in the carton as a guide, squeeze out the amount of PLIAGLIS Cream needed for your prescribed dose directly onto your treatment area.

  • Put the cap back on tightly.
  • Using the applicator included in the carton, spread PLIAGLIS Cream in an even white layer, about the thickness of a dime, over the treatment area.
  • If you get PLIAGLIS Cream on an area you do not intend to cover, wash the cream from that area.
  • Do notrub PLIAGLIS Cream into your skin.
  • Do nottouch PLIAGLIS Cream after application. Let it air dry.
  • Washyour hands.
open tube spread cream spread cream wash hands

Step 4: Leave PLIAGLIS Cream on your skin for the recommended time.

  • Your healthcare provider will tell you how long to leave PLIAGLIS Cream on your skin. Ask your healthcare provider if you are not sure how long to leave PLIAGLIS Cream on your skin.
  • If skin irritation or a burning sensation happens after applying PLIAGLIS Cream, remove the PLIAGLIS Cream right away. Wash the cream off with soap and water. Tell your healthcare provider if your skin irritation does not go away.

Step 5: Remove and throw away (discard) the dried PLIAGLIS Cream.

  • After leaving PLIAGLIS Cream on your skin the recommended amount of time, carefully peel the dried cream off your skin starting at the edges, wipe off any excess cream with a tissue or paper towel, and then throw it all away in the household trash.
  • Washyour hands after removing or touching PLIAGLIS Cream.
  • The treated area of your skin may be numb up to 9 hours.
  • Be careful with the treated skin area.
  • Do not scratch the treated skin area .Keep the treated skin area protected from extreme heat or cold until sensation returns.
remove cream remove cream discard cream wash hands

Step 6: Clean and Store Applicator

  • Wash the applicator with soap and water to remove any PLIAGLIS Cream remaining on the applicator.
  • Dry the applicator.
  • Store the applicator in the carton with the tube of PLIAGLIS Cream for future use.
clean applicator store applicator
This Instructions for Use has been approved by the U.S. Food and Drug AdministrationRevised: August 2020

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 021717 · View the label on DailyMed

Revision date stated in the text: August 2020

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Pliaglis

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Amide Local Anesthetic, Antiarrhythmic, Ester Local Anesthetic
Active ingredients Lidocaine 70 mg/g, Tetracaine 70 mg/g
Dosage form Cream
Route Topical
Marketing status listed in the FDA NDC Directory
Company (applicant) CRESCITA THERAP
FDA approval NDA 021717New Drug Application (NDA) Approved June 29, 2006
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
70 mg/g, 70 mg/g – 30 g in 1 tube / 1 in 1 carton NDC 71085-100-30

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.