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Naloxone Nasal (Narcan): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
4 mg/0.1 mL
Drug class:
Active ingredient:

Patient information: uses, side effects, how to take - Naloxone Nasal

INSTRUCTIONS FOR USE

Instructions for Use

NARCAN (nar´ kan)

(naloxone hydrochloride)

Nasal Spray

You and your family members or caregivers should read the Instructions for Use that comes with NARCAN Nasal Spray before using it. Talk to your healthcare provider if you and your family members or caregivers have any questions about the use of NARCAN Nasal Spray.

Use NARCAN Nasal Spray for known or suspected opioid overdose in adults and children.

Important: For use in the nose only.

Do not remove or test the NARCAN Nasal Spray until ready to use.

Each NARCAN Nasal Spray has 1 dose and cannot be reused.

You do not need to prime NARCAN Nasal Spray.

Howto use NARCAN Nasal Spray:

Step 1. Lay the person on their back to receive a dose of NARCAN Nasal Spray.

Step 2. Remove NARCAN Nasal Spray from the box. Peel back the tab with the circle to open the NARCAN Nasal Spray.

Step 3. Hold the NARCAN Nasal Spray with your thumb on the bottom of the plunger and your first and middle fingers on either side of the nozzle.

Step 4. Tilt the person's head back and provide support under the neck with your hand. Gently insert the tip of the nozzle into one nostril until your fingers on either side of the nozzle are against the bottom of the person's nose.

Step 5. Press the plunger firmly to give the dose of NARCAN Nasal Spray.

Step 6. Remove the NARCAN Nasal Spray from the nostril after giving the dose.

What to do after NARCAN Nasal Spray has been used:

Step 7. Get emergency medical help right away.

Move the person on their side (recovery position) after giving NARCAN Nasal Spray.

Watch the person closely.

If the person does not respond by waking up, to voice or touch, or breathing normally another dose may be given. NARCAN Nasal Spray may be dosed every 2 to 3 minutes, if available.

Repeat Steps 2 through 6 using a new NARCAN Nasal Spray to give another dose in the other nostril. If additional NARCAN Nasal Sprays are available, Steps 2 through 6 may be repeated every 2 to 3 minutes until the person responds or emergency medical help is received.

Step 8. Put the used NARCAN Nasal Spray back into its box.

Step 9. Throw away (dispose of) the used NARCAN Nasal Spray in a place that is away from children.

How should I store NARCAN Nasal Spray?

Store NARCAN Nasal Spray at room temperature between 59°F to 77°F (15°C to 25°C). NARCAN Nasal Spray may be stored for short periods up to 104°F (40°C).

Do not freeze NARCAN Nasal Spray.

Keep NARCAN Nasal Spray in the box until ready to use. Protect from light.

Replace NARCAN Nasal Spray before the expiration date on the box.

Keep NARCAN Nasal Spray and all medicines out of the reach of children.

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Distributed by Adapt Pharma, Inc. Radnor, PA 19087 USA.

For more information, go to www.narcannasalspray.com or call 1-844-4NARCAN (1-844-462-7226).

Issued: 02/2017

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 208411 · View the label on DailyMed

Revision date stated in the text: February 2017

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Naloxone Nasal

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Opioid Antagonist
Active ingredient Naloxone hydrochloride 4 mg/0.1 mL
Dosage form Spray
Route Nasal
Marketing status listed in the FDA NDC Directory
Company (applicant) EMERGENT
FDA approval NDA 208411New Drug Application (NDA) Approved November 18, 2015
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Packages (NDC)
Package
4 mg/0.1 mL – 0.1 ml in 1 vial, single-dose / 2 in 1 package NDC 51662-1240-2
4 mg/0.1 mL – 0.1 ml in 1 vial, single-dose NDC 51662-1240-1

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.