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Cortenema (Hydrocortisone): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
100 mg/60 mL
Drug class:
Active ingredient:

Patient information: uses, side effects, how to take - Cortenema

How to use the retention enema:

Best results are achieved if the bowel is emptied immediately before the enema is given.

1. Preparing the Medication for Administration

a Shake the bottle well to make sure that the suspension is homogeneous.

b Remove the protective sheath from the applicator tip. Hold the bottle at the neck so as not to cause any of the medication to be discharged.

2. Assuming the Correct Body Position

a Best results are obtained by lying on left side with the left leg extended and the right leg flexed forward for balance.

b An alternative to lying on the left side is the “knee-chest” position as shown here.

3. Administering the Retention Enema

a Gently insert the lubricated applicator tip into the rectum, pointed slightly toward the navel (umbilicus).

b Grasp the bottle firmly, then tilt slightly so that the nozzle is aimed toward the back, and squeeze slowly to instill the medication. Steady hand pressure will discharge most of the solution. After administering, withdraw and discard the used unit.

c Remain in position for at least 30 minutes to allow thorough distribution of the medication internally. Retain the enema all night, if possible.

Manufactured by

ANI Pharmaceuticals, Inc.

Baudette, MN 56623

9156 Rev 11/25

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 016199 · View the label on DailyMed

Revision date stated in the text: November 2025

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Drug information for Cortenema

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Corticosteroid
Active ingredient Hydrocortisone 100 mg/60 mL
Dosage form Enema
Route Rectal
Marketing status listed in the FDA NDC Directory
Company (applicant) ANI PHARMS
FDA approval NDA 016199New Drug Application (NDA) Approved January 12, 1966
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Therapeutic equivalence (TE) code ABCodes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
100 mg/60 mL – 60 ml in 1 bottle, unit-dose / 1 in 1 carton NDC 62559-111-11
100 mg/60 mL – 60 ml in 1 bottle, unit-dose / 7 in 1 carton NDC 62559-111-07

Source: FDA drug labeling via NLM DailyMed, data as of November 7, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.