Medication-info.com Search Menu

Clobex Topical Spray: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
0.5 mg/mL
Other brand names:
Drug class:
Active ingredient:
Similar drugs:

Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Clobex Topical Spray

What is CLOBEX ® Spray?

CLOBEX® Spray is a medicine called a topical (skin use only) corticosteroid. It is used for a short time to reduce the inflammation and itching of moderate to severe plaque psoriasis.

CLOBEX® Spray is a super-high potent (very strong) topical corticosteroid. It is very important that you use CLOBEX® Spray only as directed, in order to avoid serious side effects.

Who should not use CLOBEX ® Spray?

Do not use CLOBEX ® Spray if you are allergic to any of its ingredients, or to any other corticosteroid. The active ingredient is clobetasol propionate. See the end of this leaflet for the complete list of other ingredients in CLOBEX® Spray.

CLOBEX® Spray is not recommended for use on anyone younger than 18 years of age because the adrenal glands may shut down. (see section on “What are the possible side effects of CLOBEX ® Spray?”). Children have smaller body sizes and have a higher chance of side effects.

What should I tell my doctor before using CLOBEX ® Spray?

Tell your doctor:

  • if you are pregnant, think you are pregnant or plan to be pregnant. Talk with your doctor before using CLOBEX® Spray or if you are already using CLOBEX® Spray, as it is not known if CLOBEX® Spray can harm your unborn child.
  • if you are breastfeeding. It is not known if CLOBEX® Spray passes into your milk.
  • if you think you have a skin infection. You may need another medicine to treat the skin infection before you use CLOBEX® Spray.

Tell your doctor about all the other medicines and skin products you use, including prescription and non-prescription medicines, cosmetics, vitamins, and herbal supplements. Some medicines can cause serious side effects if used while you are using CLOBEX® Spray.

How should I use CLOBEX ® Spray?

  • Use CLOBEX® Spray exactly as directed by your doctor. CLOBEX® Spray is for skin use only.
  • Make sure your skin is clean and dry before applying CLOBEX® Spray.
  • Apply CLOBEX® Spray twice a day, once in the morning and once at night, or as directed by your doctor. Use only enough to cover the affected skin areas and rub in gently and completely. Do not exceed 30 sprays per application or 60 sprays per day. Do not apply CLOBEX® Spray to your face, underarms, or groin and avoid contact with eyes and lips.
  • Wash your hands after using CLOBEX® Spray.
  • If you forget to apply CLOBEX® Spray at the scheduled time, use it as soon as you remember. Then go back to your regular schedule. If it is about time for your next dose, apply just that one dose, and continue with your normal application schedule. Do not try to make up for the missed dose. If you miss several doses, tell your doctor.
  • Throw away unused CLOBEX® Spray.

What should I avoid while using CLOBEX ® Spray?

Do not do the following while using CLOBEX® Spray.

  • Do not get CLOBEX® Spray on your face or lips, or in or near your eyes because this might cause irritation. If you do, use a lot of water to rinse the CLOBEX® Spray off your face, lips, or out of your eyes. If your eyes keep stinging after rinsing them well with water, call your doctor right away.
  • Do not apply CLOBEX® Spray to your groin or armpits.
  • Do not bandage or cover your treated areas unless your doctor tells you to do so.
  • Do not wear tight fitting clothes over your treated skin areas.
  • Do not use CLOBEX® Spray any longer than 2 weeks (14 days) for moderate to severe psoriasis.
  • Do not use CLOBEX® Spray any longer than an extra 2 weeks (4 consecutive weeks total).
  • Do not use more than 50 grams (59 mL or 2 fluid ounces) of CLOBEX® Spray a week. CLOBEX® Spray is available in a 2 oz. and 4.25 oz bottle.

What are the possible side effects of CLOBEX ® Spray?

CLOBEX ® Spray can pass through your skin. Too much CLOBEX ® Spray passing through your skin can shut down your adrenal glands. This usually happens if you use too much CLOBEX® Spray, or you use it for too long. If this happens, your adrenal glands may not start working immediately once you stop using CLOBEX® Spray.

Shutting down of the adrenal glands can cause nausea, vomiting, fever, low blood pressure, heart attack, and even death because your body cannot respond to stress or illness. Your doctor may do special blood and urine tests to check your adrenal gland function while you are using CLOBEX® Spray.

Other possible side effects with CLOBEX® Spray include mild to moderate burning, stinging, itching, redness, irritation, and dry skin. Also, thinning of the skin, widening of small blood vessels in the skin, and skin discomfort at the site of application may happen. Sometimes your condition will get worse with use of CLOBEX® Spray.

If you go to another doctor for illness, injury, or surgery, tell that doctor that you are using CLOBEX® Spray.

Tell your doctor if you:

  • are going to have surgery
  • get sick or don't feel right. Call your doctor right away.
  • have irritation of the treated skin area that does not go away.
  • have any unusual effects that you do not understand.
  • have affected areas that do not seem to be getting better after 2 weeks of using CLOBEX® Spray.

These are not all the possible side effects of CLOBEX® Spray. For more information, ask your doctor or pharmacist.

General information about the safe and effective use of CLOBEX ® Spray.

Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use CLOBEX® Spray for a condition for which it was not prescribed. Do not give CLOBEX® Spray to other people, even if they have the same symptoms you have. It may harm them. Keep CLOBEX ® Spray and all medicines out of reach of children.

This leaflet summarizes the most important information about CLOBEX® Spray. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about CLOBEX® Spray that is written for health professionals.

What are the ingredients of CLOBEX ® Spray?

Active Ingredient: clobetasol propionate

Inactive Ingredients: alcohol, isopropyl myristate, sodium lauryl sulfate, and undecylenic acid.

Rx Only

Marketed by:

GALDERMA LABORATORIES, L.P.

Fort Worth, Texas 76177 USA

Manufactured by:

CPL

Mississauga, Ontario, Canada L5N 6L6

Made in Canada.

GALDERMA is a registered trademark.

www.clobex.com

2004953-0409

Revised: April 2009

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 021835 · View the label on DailyMed

Revision date stated in the text: April 2009

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Clobex Topical Spray

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Corticosteroid
Active ingredient Clobetasol propionate 0.5 mg/mL
Dosage form Spray
Route Topical
Marketing status not in the current FDA NDC Directory
Company (applicant) GALDERMA LABS LP
FDA approval NDA 021835New Drug Application (NDA) Approved October 27, 2005
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Therapeutic equivalence (TE) code ATCodes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Packages (NDC)
Package
0.5 mg/mL – 59 ml in 1 bottle NDC 54868-5510-0

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.