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Ziana: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
12 mg/g, 0.25 mg/g
Other brand names:
Drug class:
Active ingredients:
Similar drugs:

Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Ziana

What is ZIANA Gel?

ZIANA Gel is an antibiotic and retinoid combination medicine used for the skin treatment of acne in patients 12 years and older.

Who should not use ZIANA Gel?

Do not use ZIANA Gel if you:

  • have Crohn’s Disease
  • have Ulcerative Colitis
  • have developed colitis with past antibiotic use

Tell your doctor:

  • if you are pregnant or planning to become pregnant. It is not known if ZIANA Gel may harm your unborn baby.
  • if you are breastfeeding. ZIANA Gel may pass through your milk and may harm your baby.

  • about all the medicines and skin products you use:

    • ZIANA Gel should not be used with erythromycin-containing products.
    • Avoid medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and skin products that contain alcohol, astringents, spices or lime. These products may cause increased skin irritation if used with ZIANA Gel.

How should I use ZIANA Gel?

Use ZIANA Gel exactly as prescribed. It may take some time for you to see improvement of your acne with ZIANA Gel. Your doctor will tell you how long to use ZIANA Gel.

At bedtime:

  • Wash your face gently with a mild soap and warm water.
  • Pat the skin dry.
  • Apply a pea-size amount of ZIANA Gel to your fingertip and spread it over your face. Gently, smooth it into your skin. Do not get ZIANA Gel in your eyes or mouth, on your lips, on the corners of your nose, or on open wounds.

In the morning:

  • Apply a sunscreen and reapply during the day as needed.
  • Do not apply ZIANA Gel more than once a day.
  • Do not use too much ZIANA Gel. Too much ZIANA Gel may irritate your skin.
  • Do not wash your face more than 2 to 3 times a day. Washing your face too often or scrubbing it may make your acne worse.

Avoid:

  • excessive exposure to the sun, cold, and wind. Weather extremes can dry and burn the skin. Always use a sunscreen on ZIANA Gel treated skin, even on cloudy days. Use other protective clothing such as a hat when you are in the sun.
  • the use of sunlamps and tanning booths.

If your face becomes sunburned, stop ZIANA Gel until your skin has healed.

What are possible side effects with ZIANA Gel?

  • Skin irritation. ZIANA Gel may cause skin irritation such as dryness, redness, peeling, burning, or stinging. Stop ZIANA Gel and call your doctor if your skin becomes very red, swollen, blistered, or crusted.
  • Change in skin color. ZIANA Gel may cause a temporary skin color change (lighter or darker).
  • Colitis. This occurs rarely. Stop ZIANA Gel and call your doctor if you develop severe watery diarrhea, or bloody diarrhea.

Talk to your doctor about any side effect that bothers you or that does not go away.

These are not all the side effects with ZIANA Gel. Ask your doctor or pharmacist for more information.

How should I store ZIANA Gel?

  • Store ZIANA Gel at room temperature, 59° to 86°F (15° to 30°C). Do not freeze.
  • Keep ZIANA Gel away from heat and light.
  • Keep the tube tightly closed.
  • Keep ZIANA Gel and all medicines out of reach of children.

General information about ZIANA Gel

Medicines are sometimes prescribed for purposes other than those listed in patient information leaflet. Do not use ZIANA Gel for a condition for which it was not prescribed. Do not give ZIANA Gel to other people, even if they have the same symptoms you have. It may harm them.

This leaflet summarizes the most important information about ZIANA Gel. If you would like more information, talk with your doctor. You can also ask your pharmacist or doctor for information about ZIANA Gel that is written for healthcare professionals.

If you have questions about ZIANA Gel you can also call: 1-800-321-4576 (this is a toll-free number) between 10:00 a.m. and 4:00 p.m. Eastern Time, Monday through Friday.

What are the ingredients in ZIANA Gel?

Active Ingredients: clindamycin phosphate 1.2% and tretinoin 0.025%

Inactive Ingredients: butylated hydroxytoluene NF, carbomer 981 NF, citric acid USP, edetate disodium USP, glycerin USP, methylparaben NF, polysorbate 80 NF, propylparaben NF, purified water USP and tromethamine USP.

Distributed by:

Bausch Health US, LLC

Bridgewater, NJ 08807 USA

Manufactured by:

Bausch Health Companies Inc.

Laval, Quebec H7L 4A8, Canada

ZIANA is a registered trademark of Bausch Health Companies Inc. or its affiliates.

© 2026 Bausch Health Companies Inc. or its affiliates

Revised: 03/2026 9480202 20001130C

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 050802 · View the label on DailyMed

Revision date stated in the text: March 2026

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Ziana

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Lincosamide Antibacterial, Retinoid
Active ingredients Clindamycin phosphate 12 mg/g, Tretinoin 0.25 mg/g
Dosage form Gel
Route Topical
Marketing status listed in the FDA NDC Directory
Company (applicant) BAUSCH
FDA approval NDA 050802New Drug Application (NDA) Approved November 7, 2006
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Therapeutic equivalence (TE) code AB1Codes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Generics Clindamycin and Tretinoin, Veltin with the same TE code
Manufacturers 1 labelers list this drug on DailyMed
Packages (NDC)
Package
12 mg/g, 0.25 mg/g – 2 g in 1 tube / 12 in 1 carton NDC 99207-300-02
12 mg/g, 0.25 mg/g – 30 g in 1 tube / 1 in 1 carton NDC 99207-300-30
12 mg/g, 0.25 mg/g – 60 g in 1 tube / 1 in 1 carton NDC 99207-300-60

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.