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Xiidra (Lifitegrast): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
50 mg/mL
Active ingredient:

Patient information: uses, side effects, how to take - Xiidra

Instructions for Use

INSTRUCTIONS FOR USE

XIIDRA ®[ZYE-druh]

(lifitegrast ophthalmic solution) 5%

for topical ophthalmic use

Read this Instructions for Use before you start using Xiidra and each time you get a refill. There may be new information. This leaflet does not take the place of talking to your doctor about your medical condition or your treatment.

Important Information You Need to Know Before Using Xiidra:

  • Xiidra is for use in the eye.
  • Wash your hands before each use to make sure you do not infect your eyes while using Xiidra.
  • If you wear contact lenses, remove them before using Xiidra.
  • Xiidra single‑use containers are packaged in a foil pouch. Do not remove from the foil pouch until you are ready to use Xiidra.
  • Do not let the tip of the Xiidra single-use container touch your eye or any other surfaces.
  • Use one drop of Xiidra in each eye two times each day (one drop in the morning and one drop in the evening, approximately 12 hours apart). Each single‑use container of Xiidra will give you enough medicine to treat both of your eyes, one time. There is some extra Xiidra in each single‑use container in case you miss getting a drop into your eye. After you have applied the drops, throw away the single‑use container and any unused Xiidra. Do not save any unused Xiidra.
Follow Steps 1 to 9 each time you use Xiidra.

Step 1.Take a foil pouch out of the Xiidra box. Open the pouch and remove the strip of single‑use containers (see Figure A).

  • Pull off one single‑use container from the strip (see Figure B).
  • Figure A
  • Figure B
Step 2.Put the remaining strip of single‑use containers back in the pouch (see Figure C).
  • Figure C
  • Fold the edge to close the pouch (see Figure D).
  • Figure D

Step 3.Hold the Xiidra container upright (see Figure E).

  • Tap the top of the container until all of the solution is in the bottom part of the container (see Figure F).

Figure E

Figure F

Step 4.Open the Xiidra single‑use container by twisting off the tab. Make sure that the tip of the single‑use container does not touch anything, to avoid contamination (see Figure G).

Figure G

Step 5.Tilt your head backwards. If you are not able to tilt your head, lie down.

Step 6.Gently pull your lower eyelid downwards and look up.

Step 7.Place the tip of the Xiidra single‑use container close to your eye, but be careful not to touch your eye with it.

Step 8.Gently squeeze the single‑use container and let one drop of Xiidra fall into the space between your lower eyelid and your eye. If a drop misses your eye, try again ( see Figure H).

Figure H

Step 9. Repeat Steps 5 to 8for your other eye. There is enough Xiidra in one single‑use container for both eyes.

  • Once you have applied a drop to both eyes, throw away the opened single‑use container with any remaining solution.
  • If you use contact lenses, wait for at least 15 minutes before placing them back in your eyes.

Distributed by: Bausch & Lomb Americas Inc., Bridgewater, NJ 08807 USA

Patented. See https://patents.bausch.comfor US patent information.

Xiidra is a trademark of Bausch & Lomb Incorporated or its affiliates.

© 2023 Bausch & Lomb Incorporated or its affiliates

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Revised: December 2023

9800800

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 208073 · View the label on DailyMed

Revision date stated in the text: December 2023

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Xiidra

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Lymphocyte Function-Associated Antigen-1 Antagonist
Active ingredient Lifitegrast 50 mg/mL
Dosage form Solution/ drops
Route Ophthalmic
Marketing status listed in the FDA NDC Directory
Company (applicant) BAUSCH AND LOMB INC
FDA approval NDA 208073New Drug Application (NDA) Approved July 11, 2016
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Manufacturers 2 labelers list this drug on DailyMed
Packages (NDC)
Package
50 mg/mL – 0.2 ml in 1 ampule / 5 in 1 pouch / 12 in 1 carton NDC 24208-911-05
50 mg/mL – 0.2 ml in 1 ampule / 5 in 1 pouch / 4 in 1 carton NDC 24208-911-95

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.