Patient information: uses, side effects, how to take - Wegovy

What is the most important information I should know about WEGOVY?

WEGOVY may cause serious side effects, including:

Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, WEGOVY and other medicines that work like WEGOVY caused thyroid tumors, including thyroid cancer. It is not known if WEGOVY will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.
Do not use WEGOVY if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC), or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

What is WEGOVY?

WEGOVY injection is a prescription medicine used with a reduced-calorie diet and increased physical activity to:
reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight.
help adults and children aged 12 years and older with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to lose weight and keep the weight off.
treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
WEGOVY tablets are a prescription medicine used with a reduced-calorie diet and increased physical activity to:
- reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight.
- help adults with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to lose weight and keep the weight off.
WEGOVY contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
It is not known if WEGOVY injection is safe and effective:
to reduce the risk of major cardiovascular events (death, heart attack, or stroke) in people under 18 years.
to help children under 12 years of age lose weight and keep the weight off.
for the treatment of MASH in people under 18 years of age.
It is not known if WEGOVY tablets are safe and effective for use in people under 18 years of age.

Do not use WEGOVY if:

you or any of your family have ever had a type of thyroid cancer called MTC or if you have an endocrine system condition called MEN 2.
you have had a serious allergic reaction to semaglutide or any of the ingredients in WEGOVY injection or WEGOVY tablets. See the end of this Medication Guide for a complete list of ingredients in WEGOVY injection and WEGOVY tablets. See “What are the possible side effects of WEGOVY?” for symptoms of a serious allergic reaction.

Before using WEGOVY, tell your healthcare provider if you have any other medical conditions, including if you:

have or have had problems with your pancreas or kidneys.
have type 2 diabetes and a history of diabetic retinopathy.
are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation).
are pregnant or plan to become pregnant. WEGOVY may harm your unborn baby. You should stop using WEGOVY 2 months before you plan to become pregnant.
Pregnancy Exposure Registry: There is a pregnancy exposure registry for women who use WEGOVY during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry or you may contact Novo Nordisk at 1-877-390-2760 or www.wegovypregnancyregistry.com.
are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with WEGOVY tablets. It is not known if WEGOVY when received through an injection passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using WEGOVY.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. WEGOVY may affect the way some medicines work and some medicines may affect the way WEGOVY works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. WEGOVY slows stomach emptying and can affect medicines that need to pass through the stomach quickly.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I use WEGOVY?

Use WEGOVY exactly as your healthcare provider tells you to.
Use WEGOVY with a reduced-calorie diet and increased physical activity.
If you take too much WEGOVY, you may have severe nausea, severe vomiting and severe low blood sugar. Call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away. Advice is also available online at poisonhelp.org.

WEGOVY Injection

Read the Instructions for Use that comes with WEGOVY.
Your healthcare provider should tell you which WEGOVY product you will be using (for example – single-dose pen or syringe, single-patient-use pen, or tablets). Before you use WEGOVY injection for the first time, your healthcare provider should show you how to use it. Once you have been trained, you may inject WEGOVY yourself if your healthcare provider determines that you are able to do so safely. If you are visually impaired, the WEGOVY FlexTouch pen is not recommended for self-injection.
If you are prescribed a different WEGOVY product at any point, make sure you receive new training for the new product and read the Instructions for Use that come with it.
WEGOVY is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Do not inject WEGOVY into a muscle (intramuscularly) or vein (intravenously).
Change (rotate) your injection site with each injection. Do not use the same site for each injection.
Use WEGOVY 1 time each week, on the same day each week, at any time of the day.
If you need to change the day of the week, you may do so as long as your last dose of WEGOVY was given 2 or more days before.
If you miss a dose of WEGOVY and the next scheduled dose is more than 2 days away (48 hours), take the missed dose as soon as possible. If you miss a dose of WEGOVY and the next scheduled dose is less than 2 days away (48 hours), do not administer the dose. Take your next dose on the regularly scheduled day.
If you miss doses of WEGOVY for 2 or more consecutive weeks, contact your healthcare provider to talk about how to restart your treatment.
You can take WEGOVY with or without food.

WEGOVY Tablets

Take 1 WEGOVY tablet by mouth on an empty stomach in the morning with water (no more than 4 ounces). Do not take WEGOVY tablets with any other liquids besides water.
Do not split, crush, chew or dissolve WEGOVY tablets. Swallow WEGOVY tablets whole.
Do not take more than 1 WEGOVY tablet each day.
After 30 minutes, you can eat, drink, or take other oral medicines.
If you miss a dose of WEGOVY, skip the missed dose and go back to your regular schedule for the next dose.

What are the possible side effects of WEGOVY?

WEGOVY may cause serious side effects, including:

See “What is the most important information I should know about WEGOVY?”
inflammation of your pancreas (pancreatitis). Stop using WEGOVY and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back.
gallbladder problems. WEGOVY may cause gallbladder problems including gallstones. Some gallbladder problems need surgery. Call your healthcare provider if you have any of the following symptoms:

pain in your upper stomach (abdomen)

yellowing of skin or eyes (jaundice)

fever

clay-colored stools

increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines to treat type 2 diabetes mellitus such as an insulin or a sulfonylureas. Low blood sugar in patients with type 2 diabetes who receive WEGOVY can be both a serious and common side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar. You should check your blood sugar before you start taking WEGOVY and while you take WEGOVY. Signs and symptoms of low blood sugar may include:

dizziness or light-headedness

sweating

shakiness

blurred vision

slurred speech

weakness

anxiety

hunger

headache

irritability or mood changes

confusion or drowsiness

fast heartbeat

feeling jittery

dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.
severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use WEGOVY. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
serious allergic reactions. Stop using WEGOVY and get medical help right away, if you have any symptoms of a serious allergic reaction including:

swelling of your face, lips, tongue or throat

severe rash or itching

very rapid heartbeat

problems breathing or swallowing

fainting or feeling dizzy

change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with WEGOVY.
increased heart rate. WEGOVY can increase your heart rate while you are at rest. Your healthcare provider should check your heart rate while you take WEGOVY. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes.
food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). WEGOVY may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking WEGOVY before you are scheduled to have surgery or other procedures.
The most common side effects of WEGOVY in adults or children aged 12 years and older may include:

nausea

stomach (abdomen) pain

dizziness

diarrhea

changes in skin sensations

feeling bloated

vomiting

headache

belching

stomach flu

constipation

tiredness (fatigue)
upset stomach

low blood sugar in people with type 2 diabetes

heartburn
hair loss

Talk to your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of WEGOVY.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088.

How should I store WEGOVY?

WEGOVY injection

Do not store WEGOVY in the freezer or directly beside the refrigerator cooling element.
Do not freeze WEGOVY and do not use WEGOVY if it has been frozen.
WEGOVY single-dose pen and single-dose syringe:
- Store in the refrigerator between 36°F to 46°F (2°C to 8°C).
- If needed, before removing the pen or syringe cap, WEGOVY single-dose pen and single-dose syringe can be stored from 46°F to 86°F (8°C to 30°C) in the original carton for up to 28 days.
- Keep WEGOVY single-dose pen and syringe in the original carton to protect it from light.
- Throw away the WEGOVY single-dose pen or syringe if it has been frozen, has been exposed to light or temperatures above 86°F (30°C), has been out of the refrigerator for 28 days or longer, or after use.
WEGOVY FlexTouch single-patient-use pen:
- Store in the refrigerator between 36°F to 46°F (2°C to 8°C).
- After first use, store WEGOVY FlexTouch pen between 59°F to 86°F (15°C to 30°C) or in the refrigerator between 36°F to 46°F (2°C to 8°C) for up to 56 days.
- Protect WEGOVY FlexTouch pen from excessive heat and light.
- Keep the pen cap on when not in use.
- Always remove and safely discard the needle after each injection.
- Store WEGOVY FlexTouch pen without an injection needle attached.
- Always use a new needle for each injection.
- Throw away if the WEGOVY FlexTouch pen if it has been frozen, has been exposed to light or temperatures above 86°F (30°C), or has been out of the refrigerator for 56 days or longer.

WEGOVY tablets

Store WEGOVY tablets at room temperature between 68°F to 77°F (20°C to 25°C).
Store tablets in the original closed WEGOVY bottle until you are ready to take one. Do not store in any other container.
Store in a dry place away from moisture.

Keep WEGOVY and all medicines out of the reach of children.

General information about the safe and effective use of WEGOVY.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use WEGOVY for a condition for which it was not prescribed. Do not give WEGOVY to other people, even if they have the same condition that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about WEGOVY that is written for health professionals.

What are the ingredients in WEGOVY?

Active Ingredient: semaglutide

Inactive Ingredients in WEGOVY injection:disodium phosphate dihydrate, sodium chloride, water for injection. Phenol and propylene glycol are also inactive ingredients in the single-patient-use WEGOVY FlexTouch. Hydrochloric acid or sodium hydroxide may be added to adjust pH.

Inactive Ingredients in WEGOVY tablets: salcaprozate sodium (SNAC) and magnesium stearate

Marketed by: Novo Nordisk Inc., Plainsboro, NJ 08536

WEGOVY ^®and FlexTouch ^®are registered trademarks of Novo Nordisk A/S.

Patent Information: http://novonordisk-us.com/products/product-patents.html

For more information, go to startWegovy.com or call 1-833-Wegovy-1.

This Medication Guide has been approved by the U.S. Food and Drug Administration. Revised: 06/2026

Instructions for Use – Pen

Instructions for Use

WEGOVY^®

(semaglutide) injection

WEGOVY comes in five strengths:

Before you use your WEGOVY pen for the first time, talk to your healthcare provider or your caregiver about how to prepare and inject WEGOVY correctly.

Important information

Read this Instructions for Use before you start using WEGOVY. This information does not replace talking to your healthcare provider about your medical condition or treatment.

Your WEGOVY pen is for 1 time use only. The WEGOVY pen is for subcutaneous (under the skin) use only.
The dose of WEGOVY is already set on your pen.
The needle is covered by the needle cover and the needle will not be seen.
Do not remove the pen cap until you are ready to inject.
Do not touch or push on the needle cover. You could get a needle stick injury.
Your WEGOVY injection will start when the needle cover is pressed firmly against your skin.
Do not remove the pen from your skin before the yellow bar in the pen window has stopped moving. The medicine may appear on the skin or squirt from the needle and you may not get your full dose of WEGOVY if:
the pen is removed too early or
you have not pressed the pen firmly against the skin for the entire injection.
If the yellow bar does not start moving or stops during the injection, contact your healthcare provider or Novo Nordisk at startWegovy.com or call Novo Nordisk Inc. at 1-833-934-6891.
The needle cover will lock when the pen is removed from your skin. You cannot stop the injection and restart it later.
People who are blind or have vision problems should not use the WEGOVY pen without help from a person trained to use the WEGOVY pen.

How do I store WEGOVY?

Store the WEGOVY pen in the refrigerator between 36°F to 46°F (2°C to 8°C).
If needed, before removing the pen cap, WEGOVY can be stored from 46°F to 86°F (8°C to 30°C) in the original carton for up to 28 days.
Keep WEGOVY in the original carton to protect it from light.
Do not freeze.
Throw away the pen if WEGOVY has been frozen, has been exposed to light or temperatures above 86°F (30°C), or has been out of the refrigerator for 28 days or longer.

Keep WEGOVY and all medicines out of the reach of children.

How to use your WEGOVY pen

Do not use your WEGOVY pen without receiving training from your healthcare provider. Make sure that you or your caregiver know how to give an injection with the pen before you start your treatment.

Read and follow the instructions so that you use your WEGOVY pen correctly:

Preparation

Step 1. Prepare for your injection.

Supplies you will need to give your WEGOVY injection:
WEGOVY pen
1 alcohol swab or soap and water
1 gauze pad or cotton ball
1 sharps disposable container for used WEGOVY pens

Wash your hands.
Check your WEGOVY pen.
Do not use your WEGOVY pen if:
The pen appears to have been used or any part of the pen appears broken, for example if it has been dropped.
The WEGOVY medicine is not clear and colorless through the pen window.
The expiration date (EXP) has passed.

Contact Novo Nordisk at 1-833-934-6891 if your WEGOVY pen fails any of these checks.

Step 2. Choose your injection site.

Your healthcare provider can help you choose the injection site that is best for you
- You may inject into your upper leg (front of the thighs), lower stomach (keep 2 inches away from your belly button) or upper arm.
Do not inject into an area where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks.
You may inject in the same body area each week, but make sure it is not in the same spot each time.

Clean the injection site with an alcohol swab or soap and water. Do not touch the injection site after cleaning. Allow the skin to dry before injecting.

Injection

Step 3. Remove pen cap.

Pull the pen cap straight off your pen.

Step 4. Inject WEGOVY.

Push the pen firmly against your skin and keep applying pressure until the yellow bar has stopped moving.
If the yellow bar does not start moving, press the pen more firmly against your skin.
You will hear 2 clicks during the injection.
Click 1: the injection has started.
Click 2: the injection is ongoing.
If you have problems with the injection, refer to the “Troubleshooting” section.

Throw away pen

Step 5. Throw away (dispose of) pen.

Safely dispose of the WEGOVY pen right away after each use. See “How do I throw away (dispose of) WEGOVY pens?”

What if blood appears after injection?
If blood appears at the injection site, press the site lightly with a gauze pad or cotton ball.

If you have problems injecting, change to a more firm injection site, such as upper leg, or upper arm or consider standing up while injecting into the lower stomach.
If medicine appears on the skin or squirts from the needle, make sure the next time you inject to keep applying pressure until the yellow bar has stopped moving. Then you can lift the pen slowly from your skin.

How do I throw away (dispose of) WEGOVY pens?

Put the used WEGOVY pen in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) the pen in your household trash.

If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:

made of a heavy-duty plastic,
able to be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
upright and stable during use,
leak-resistant, and
properly labeled to warn of hazardous waste inside the container.

When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific sharps disposal in the state that you live in, go to the FDA’s website at http://www.fda.gov/safesharpsdisposal.

Do not reuse the pen.
Do not recycle the pen or sharps disposal container, or throw them into household trash.

Important: Keep your WEGOVY pen, sharps disposal container and all medicines out of the reach of children.

How do I care for my pen?

Protect your pen

Do not drop your pen or knock it against hard surfaces.
Do not expose your pen to any liquids.
If you think that your pen may be damaged, do not try to fix it. Use a new one.
Keep the pen cap on until you are ready to inject. Your pen will no longer be sterile if you store an unused pen without the cap, if you pull the pen cap off and put it on again, or if the pen cap is missing. This could lead to an infection.
If you have any questions about WEGOVY, go to startWegovy.com or call Novo Nordisk Inc. at 1-833-Wegovy-1

Marketed by:

Novo Nordisk Inc.

Plainsboro, NJ 08536

For information about WEGOVY, go to

startWegovy.com or contact:

Novo Nordisk Inc.

800 Scudders Mill Road

Plainsboro, NJ 08536

1-833-Wegovy-1

WEGOVY ^®is a registered trademark of Novo Nordisk A/S.

Patent Information: http://novonordisk-us.com/products/product-patents.html

This Instructions for Use has been approved by the U.S. Food and Drug Administration. Revised: November 2025

Instructions for Use – WEGOVY HD

Instructions for Use

WEGOVY^®HD

(semaglutide) injection

WEGOVY HD comes in the following strength:

Before you use your WEGOVY pen for the first time, talk to your healthcare provider or your caregiver about how to prepare and inject WEGOVY correctly.

Important information

Read this Instructions for Use before you start using WEGOVY. This information does not replace talking to your healthcare provider about your medical condition or treatment.

Your WEGOVY pen is for 1 time use only. The WEGOVY pen is for subcutaneous (under the skin) use only.
The dose of WEGOVY is already set on your pen.
The needle is covered by the needle cover and the needle will not be seen.
Do not remove the pen cap until you are ready to inject.
Do not touch or push on the needle cover. You could get a needle stick injury.
Your WEGOVY injection will start when the needle cover is pressed firmly against your skin.
Do not remove the pen from your skin before the yellow bar in the pen window has stopped moving. The medicine may appear on the skin or squirt from the needle and you may not get your full dose of WEGOVY if:
the pen is removed too early or
you have not pressed the pen firmly against the skin for the entire injection.
If the yellow bar does not start moving or stops during the injection, contact your healthcare provider or Novo Nordisk at startWegovy.com or call Novo Nordisk Inc. at 1-833-934-6891.
The needle cover will lock when the pen is removed from your skin. You cannot stop the injection and restart it later.
People who are blind or have vision problems should not use the WEGOVY pen without help from a person trained to use the WEGOVY pen.

How do I store WEGOVY?

Store the WEGOVY pen in the refrigerator between 36°F to 46°F (2°C to 8°C).
If needed, before removing the pen cap, WEGOVY can be stored from 46°F to 86°F (8°C to 30°C) in the original carton for up to 28 days.
Do not store WEGOVY in the freezer or directly beside the refrigerator cooling element.
Do not freeze WEGOVY and do not use if it has been frozen.
Keep WEGOVY in the original carton to protect it from light.
Throw away the pen if WEGOVY has been frozen, has been exposed to light or temperatures above 86°F (30°C), or has been out of the refrigerator for 28 days or longer or after use.

Keep WEGOVY and all medicines out of the reach of children.

WEGOVY pen parts

How to use your WEGOVY pen

Read and follow the instructions so that you use your WEGOVY pen correctly:

Preparation

Step 1. Prepare for your injection.

Supplies you will need to give your WEGOVY injection:
WEGOVY pen
1 alcohol swab or soap and water
1 gauze pad or cotton ball
1 sharps disposable container for used WEGOVY pens

Wash your hands.
Check your WEGOVY pen.
Do not use your WEGOVY pen if:
The pen appears to have been used or any part of the pen appears broken, for example if it has been dropped.
The WEGOVY medicine is not clear and colorless through the pen window.
The expiration date (EXP) has passed.

Contact Novo Nordisk at 1-833-934-6891 if your WEGOVY pen fails any of these checks.

Step 2. Choose your injection site.

Your healthcare provider can help you choose the injection site that is best for you.
You may inject into your upper leg (front of the thighs), lower stomach (keep 2 inches away from your belly button) or upper arm.
Do not inject into an area where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks.
You may inject in the same body area each week, but make sure it is not in the same spot each time.

Clean the injection site with an alcohol swab or soap and water. Do not touch the injection site after cleaning. Allow the skin to dry before injecting.

Injection

Step 3. Remove pen cap.

Pull the pen cap straight off your pen.

Step 4. Inject WEGOVY.

Push the pen firmly against your skin and keep applying pressure until the yellow bar has stopped moving.
If the yellow bar does not start moving, press the pen more firmly against your skin.
You will hear 2 clicks during the injection.
Click 1: the injection has started.
Click 2: the injection is ongoing.
If you have problems with the injection, refer to the “Troubleshooting” section.

Throw away pen

Step 5. Throw away (dispose of) pen.

Safely dispose of the WEGOVY pen right away after each use. See “How do I throw away (dispose of) WEGOVY pens?”

What if blood appears after injection?

If blood appears at the injection site, press the site lightly with a gauze pad or cotton ball.

ⓘ Troubleshooting

If you have problems injecting, change to a more firm injection site, such as upper leg, or upper arm or consider standing up while injecting into the lower stomach.
If medicine appears on the skin or squirts from the needle, make sure the next time you inject to keep applying pressure until the yellow bar has stopped moving. Then you can lift the pen slowly from your skin.

How do I throw away (dispose of) WEGOVY pens?

Put the used WEGOVY pen in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) the pen in your household trash.

If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:

made of a heavy-duty plastic,
able to be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
upright and stable during use,
leak-resistant, and
properly labeled to warn of hazardous waste inside the container.

Do not reuse the pen.
Do not recycle the pen or sharps disposal container, or throw them into household trash.

Important: Keep your WEGOVY pen, sharps disposal container and all medicines out of the reach of children.

⚠ How do I care for my pen?

Protect your pen

Do not drop your pen or knock it against hard surfaces.
Do not expose your pen to any liquids.
If you think that your pen may be damaged, do not try to fix it. Use a new one.
Keep the pen cap on until you are ready to inject. Your pen will no longer be sterile if you store an unused pen without the cap, if you pull the pen cap off and put it on again, or if the pen cap is missing. This could lead to an infection.
✆ If you have any questions about WEGOVY, go to startWegovy.com or call Novo Nordisk Inc. at
1-833-Wegovy-1

Marketed by:

Novo Nordisk Inc.

Plainsboro, NJ 08536

For information about WEGOVY, go to startWegovy.com

or contact:

Novo Nordisk Inc.

800 Scudders Mill Road

Plainsboro, NJ 08536

1-833-Wegovy-1

Wegovy^®is a registered trademark of Novo Nordisk A/S.

Patent Information: http://novonordisk-us.com/products/product-patents.html

This Instructions for Use has been approved by the U.S. Food and Drug Administration. Revised: 03/2026

Instructions for Use – Manual Prefilled Syringe

INSTRUCTIONS FOR USE

WEGOVY^®[wee-GOH-vee]

(semaglutide)

injection, subcutaneous only

single-dose prefilled syringe

Before using your prefilled syringe, always read these instructions carefully.

This leaflet instructs how to perform an injection under the skin (subcutaneous).

The prefilled syringe might be different than any other device you have used previously.

Before you use your prefilled syringe, talk to your healthcare provider about how to inject your prefilled syringe correctly.

Get to Know Your Prefilled Syringe

You should check the label on the carton and prefilled syringe to ensure it contains the correct medicine. Please make sure you have the correct dose prescribed by your healthcare provider.

Important Information You Need to Know Before Injecting with your Prefilled Syringe

Use the prefilled syringe exactly the way your healthcare provider tells you to.
The prefilled syringe contains 1 complete dose. It is for one-time use only.
Do not use the prefilled syringe if the carton is damaged or if the tamper-evident is broken.
Do not warm the prefilled syringe using any heat sources such as hot water or a microwave.
Do not use the prefilled syringes if the expiration date on the label or carton has expired.
Do not use the prefilled syringe if it has been frozen or thawed.

People who are blind or have vision problems should not use the prefilled syringe without help from a person who knows how to use the prefilled syringe.

Gather the Following Materials Before Your Injection

1 WEGOVY prefilled syringe
alcohol wipe
cotton ball or gauze
sharps disposal container for used prefilled syringes

Not Included in Your Carton

Frequently Asked Questions

Do I inject the full volume of the prefilled syringe?

Yes, the prefilled syringe is for one-time (single) use and contains one complete dose.

What if the prefilled syringe is damaged?

Do not use a dropped, damaged or broken prefilled syringe. Take a new prefilled syringe for your injection.

What if the needle is broken?

Do not use a needle that appears to be bent, dropped, damaged or broken. Take a new prefilled syringe for your injection.

If you have any questions about WEGOVY, go to startWEGOVY.com or call Novo Nordisk Inc. at 1-833-Wegovy-1.

Prepare Your Prefilled Syringe

1. Take One Prefilled Syringe
• Wash and dry your hands.
• Open the carton.
• Gently take out one prefilled syringe by holding the glass barrel.
• Check the syringe label. Confirm you have the dose prescribed by your healthcare provider.

Do not hold or touch the prefilled syringe by the plunger rod or needle cap.

Keep the needle cap on until you are ready to inject.

2. Inspect your Prefilled Syringe
• Check the expiration date (EXP) on the label has not passed.
• Check that the medicine in the prefilled syringe is clear and colorless. If the medicine looks cloudy or contains particles, do not use the prefilled syringe.

It is normal to see air bubbles; they do not affect your dose. Do not try to remove bubbles.

Do not use the prefilled syringe if it appears to have been used, dropped, damaged or broken.

3. Choose Your Injection Site

Inject into the skin of:

stomach area (abdomen) at least 2 inches from the belly button.
thighs.
back of upper arm (only with help from someone else).

Clean the injection site with an alcohol wipe and allow to dry. Your healthcare provider can help you choose the injection site that is best for you.

Avoid using the exact same spot as the last time between injections.

Inject Your Dose

4. Pull Off the Needle Cap
• Pull the needle cap straight off and throw it in a sharps disposal container.

You might see drops of medicine from the needle tip. This is normal and does not affect your dose. Continue with your injection right away.

Do not put the needle cap back on, to avoid needle stick injuries.

5. Insert Your Prefilled Syringe
• Pinch and hold a fold of skin at the injection site between your thumb and fingers. Hold the pinch throughout the injection.
• Fully insert the needle into the pinched skin at a 45-degree angle.

This is to inject under the skin (subcutaneous) and not the muscle.

6. Inject Your Dose
• Keep a 45-degree angle. With a constant pressure, gently push the plunger rod all the way down until the plunger stops.

When the plunger is at the bottom and the prefilled syringe is empty, your dose is complete.

7. Remove Your Syringe
• Pull out the empty syringe at a 45-degree angle. Your injection is complete.

If blood appears at the injection site, lightly press with a cotton ball or gauze over it, without rubbing.

Do not put the needle cap back on the syringe.

After Injection

8. Dispose of (Throw Away) Your Used Syringe
• Put the used syringe in an FDA-cleared sharps disposal container right away after use.
• If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:
o made of a heavy-duty plastic,
o can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
o upright and stable during use,
o leak-resistant, and
o properly labeled to warn of hazardous waste inside the container.
• When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
• Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.

Safely dispose of your syringe that is out of date or no longer needed.

Keep your syringe and all medicines out of the reach of children.

How Should I Store My WEGOVY Prefilled Syringe?

Store the unused WEGOVY prefilled syringes in the refrigerator between 36°F to 46°F (2°C to 8°C).
If needed, the prefilled syringes can be stored out of the refrigerator between 46°F to 86°F (8°C to 30°C) for up to 28 days. Record the date your prefilled syringe was removed from the refrigerator and dispose of it if not used within 28 days.
Do not freeze.
Always keep the prefilled syringes in the original carton to protect from light.

Keep the prefilled syringe and all medicines out of the reach of children.

Marketed by:

Novo Nordisk Inc.

Plainsboro, NJ 08536

For information about WEGOVY, contact:

Novo Nordisk Inc.

800 Scudders Mill Road

Plainsboro, NJ 08536

1-833-Wegovy-1

Wegovy^®is a registered trademark of Novo Nordisk A/S.

Patent Information:

http://www.novonordisk-us.com/products/product-patents.html

The Instructions for Use has been approved by the U.S Food and Drug Administration. Approved: 05/2026

Instructions for Use - FlexTouch

INSTRUCTIONS FOR USE WEGOVY^®(wee-GOH-vee) FlexTouch^® (semaglutide) injection, for subcutaneous use 2.4 mg dose single-patient-use pen Each pen contains 4 fixed doses, one dose taken weekly
Unfold the whole leaflet and read these instructions carefully before using your WEGOVY FlexTouch single-patient-use pen. This single-patient-use pen contains four doses of WEGOVY 2.4 mg. If you have been using a single-dose WEGOVY pen until now, please get familiar with your WEGOVY FlexTouch single-patient-use pen and needles. Do not use your pen without proper training from your healthcare provider. Make sure that you know how to give yourself an injection with the pen before you start your treatment. Do not share your WEGOVY pen with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them. If you are blind or have poor eyesight and cannot read the dose counter on the pen, do not use this pen without help. Get help from a person with good eyesight who is trained to use the WEGOVYpen. Please use the table inside the lid of the carton to keep track of how many injections you have used and how many doses remain in your pen. Start by checking your pen to make sure that it contains WEGOVY, then look at the pictures in this ‘Instructions for Use’ to get to know the different parts of your pen and needle. Your pen is a prefilled, single-patient-use, dial-a-dose pen. One pen contains 4 doses of 2.4 mg. You can only select doses of 2.4 mg . NovoFine^®Plus 32G 4 mm disposable needles are included with your WEGOVY FlexTouch pen. Always use a new needle for each injection. If you need additional needles, NovoFine^®Plus, NovoFine^®or other compatible disposable needles with a length up to 8 mm can be used. For needle compatibility information, talk to your healthcare professional. Supplies you will need to give your WEGOVY injection: WEGOVY FlexTouch pen 2.4 mg dose a new NovoFine Plus or NovoFine needle or other compatible needle alcohol swab cotton ball or gauze an FDA-cleared sharps disposal container for throwing away used WEGOVY pens and needles. See Step 5 ‘After your injection’ for information concerning disposal.

Step 1. Prepare your pen with a new needle
Wash your hands with soap and water. Check the name and colored label of your pen, to make sure that it contains your 2.4 mg dose of WEGOVY. This is especially important if you take more than 1 type of medicine. Pull off the pen cap. See Figure A.
Check that the medicinein your pen is clear and colorless. Look through the pen window. If the medicinelooks cloudy, do not use the pen. See Figure B.
Do not attach a new needle to your pen until you are ready to take your injection. Take a new needle, and tear off the paper tab. See Figure C.
Push the needle straight onto the pen. Turn until it is on tight. See Figure D.
The needle is covered by 2 caps. You must remove both caps. If you forget to remove both caps, you will not inject any medicine. Pull off the outer needle cap. Do not throw it away. See Figure E. Pull off the inner needle cap and throw it away. See Figure F. A drop of medicinemay appear at the needle tip. This is normal, but you must still check the medicine flow, if you use a new pen for the first time. Never use a bent or damaged needle. Always use a new needle for each injection. This will prevent contamination, infection, leakage of medicine, and blocked needles leading to the wrong dose.
Do not reuse or share your needles with other people. You may give other people a serious infection or get a serious infection from them.
Step 2. Check the flow with each new pen
Before you inject your first dose with your new pen, check the medicineflow. For your second, third and fourth dose with this pen, go to Step 3. Set your dose.
Turn the dose selector until the dose counter shows the flow check symbol ( ). See Figure G. Make sure that the flow check symbol lines up with the dose pointer.
Hold the pen with the needle pointing up. Press and hold in the dose button until the dose counter shows . The must line up with the dose pointer. See Figure H. A drop of medicinewill appear at the needle tip. If no drop appears, check the flow again. This should only be done twice. If there is still no drop of medicine, change the needle and check the flow 1 more time. Do not use the pen if a drop of medicinestill does not appear. Always make sure that a drop of medicine appears at the needle tip before you use a new pen for the first time. This makes sure that the medicineflows. If no drop of medicine appears, you will not inject any medicine, even though the dose counter may move. This may mean that there is a blocked or damaged needle. A small drop of medicine may remain at the needle tip, but it will not be injected. Only check the medicineflow before your first injection with each new pen.
Step 3. Set your dose
Turn the dose selector until the dose counter stops, and it shows your 2.4 mg dose. See Figure I.
The dashed line in the dose counter will guide you to your 2.4 mg dose. See Figure J. The dose selector clicks differently when turned forward or backwards. You will hear a ‘click’ every time you turn the dose selector. Do not set the dose by counting the number of clicks you hear. You can only select 2.4 mg for each dose. When your pen contains less than 2.4 mg, the dose counter stops before 2.4 mg is shown. There is not enough medicine for your dose injection. When your prescribed dose of 2.4 mg lines up with the dose pointer, you have selected your dose. See Figure I. If the dose counter stops before you reach your prescribed dose, see the section ‘Do you have enough medicine?’.
Do you have enough medicine?
If the dose counter stops before you reach your prescribed dose of 2.4 mg, there is not enough medicine left for a full dose. Throw away (dispose of) the pen and use a new WEGOVY pen.
Choose your injection site
Choose an injection site on your upper arms, stomach or upper legs. Keep a distance of 2 inches (5 cm) from your belly button. See image for locations. You may inject in the same body area each week, but make sure it is not in the same spot used for the last injection. Wipe the skin with an alcohol swab. Let the injection site dry before you inject your dose.
Step 4. Inject your dose
Insert the needle into your skin as your healthcare provider has shown you. See Figure L. Make sure you can see the dose counter. Do not cover it with your fingers. This could stop the injection.
Press and hold down the dose button until the dose counter shows . The must line up with the dose pointer. You may then hear or feel a click. See Figure M.
Continue pressing the dose button while keeping the needle in your skin and count slowly to 6. See Figure N. If the needle is removed earlier, you may see a stream of medicinecoming from the needle tip. If this happens, the full dose will not be delivered.
Remove the needle from your skin. You can then release the dose button. See Figure O. If blood appears at the injection site, press the site lightly with a cotton ball or gauze. Do not rub the area. You may see a drop of medicineat the needle tip after injecting. This is normal and does not affect your dose. Always watch the dose counter to make sure you have injected your complete dose. Hold the dose button down until the dose counter shows . How to identify a blocked or damaged needle? If does not appear in the dose counter after continuously pressing the dose button, you may have used a blocked or damaged needle. If this happens you have not received any medicine even though the dose counter has moved from the original dose that you have selected. How to handle a blocked needle? Change the needle as described in Step 1: “Prepare your pen with a new needle”. Make sure you select the full dose you need. Never touch the dose counter when you inject. This can stop the injection.
Step 5. After your injection
Carefully unscrew the needle from the pen. Do not put the needle caps back on the needle, to avoid needle sticks. See Figure P.
Place the needle in an FDA-cleared sharps container right away to reduce the risk of needle sticks. See Figure Q.
Put the pen cap on your pen after each use to protect the medicinefrom light. See Figure R.
If you do not have an FDA-cleared sharps disposal container, follow a one-handed needle recapping method. Carefully slip the needle into the outer needle cap. Push the capped needle against a firm, vertical surface until you hear a “click.” Twist off the capped needle from the pen and dispose of the needle in an FDA-cleared sharps disposal container as soon as possible or in a household container as listed in ‘Disposing of used pens and needles’. See Figure S. Never try to put the inner needle cap back on the needle. You may stick yourself with the needle. Always remove the needle from your pen. This prevents contamination, infection, leakage of medicine, and blocked needles leading to the wrong dose. If the needle is blocked, you will not inject any medicine. Always throw away (dispose of) the needle after each injection. Throwing away (disposing of) used pens and needles: After having injected all four doses, there may still be medicine left in the pen. The pen should be thrown away (disposed of). Put your used WEGOVY pen and needle in an FDA-cleared sharps disposal container right away after use. If you do not have an FDA-cleared sharps disposal container, you may use a household container that is: made of a heavy-duty plastic can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out upright and stable during use leak-resistant properly labeled to warn of hazardous waste inside the container. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needle and syringes. For more information about the safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal. Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container. Safely dispose of medicine that is out of date or no longer needed.
Important
Caregivers must be very careful when handling used needles to prevent needle sticks and cross infection. Never use a syringe to withdraw medicinefrom your pen. Always keep your pen and needles out of reach of others, especially children. Do not share your pen or needles with anyone else. You may give an infection to them or get an infection from them. Do not leave it in a car or other place where it can get too hot or too cold.
Caring for your pen
Do not drop your pen or knock it against hard surfaces. If you drop it or suspect a problem, attach a new needle and check the medicine flow before you inject. Do not try to repair your pen or pull it apart. Do not expose your pen to dust, dirt, or liquid. Do not wash, soak, or lubricate your pen. If necessary, clean it with mild detergent on a moistened cloth. How should I store my WEGOVY pen? Store in the refrigerator between 36°F to 46°F (2°C to 8°C). After first use, store WEGOVY FlexTouch between 68°F to 77°F (20°C to 25°C) or in a refrigerator 36°F to 46°F (2°C to 8°C) for up to 56 days. WEGOVY should be protected from excessive heat and light. Keep the pen cap on when not in use. Always remove and safely discard the needle after each injection. Store the single-patient-use WEGOVY FlexTouch pen without an injection needle attached. Throw away if the single-patient-use WEGOVY FlexTouch pen has been frozen, has been exposed to light or temperatures above 86°F (30°C), or has been out of the refrigerator for 56 days or longer.
Marketed by: Novo Nordisk Inc. Plainsboro, NJ 08536 For information about WEGOVY, contact: Novo Nordisk Inc. 800 Scudders Mill Road Plainsboro, NJ 08536 1-833-wegovy-1 (se habla español) © 2026 Novo Nordisk WEGOVY^®, FlexTouch^®, NovoFine^®and NovoFinePlus^®are registered trademarks of Novo Nordisk A/S. Patent Information: http://novonordisk-us.com/products/product-patents.html
This Instructions for Use has been approved by the U.S. Food and Drug Administration. Revised 06//2026