Voriconazole Injection (Vfend): Uses, Side Effects and Dosage

What is Voriconazole for Injection?

Voriconazole for Injection is a prescription medicine used to treat certain serious fungal infections in your blood and body. These infections are called “aspergillosis,” “esophageal candidiasis,” “Scedosporium,” “Fusarium,” and “candidemia”.

It is not known if Voriconazole for Injection is safe and effective in children younger than 2 years old.

Do not take Voriconazole for Injection if you:

• are allergic to voriconazole or any of the ingredients in Voriconazole for Injection. See the end of this leaflet for a complete list of ingredients in Voriconazole for Injection.
• are taking any of the following medicines:

• carbamazepine
• efavirenz
• eplerenone

• ergotamine, dihydroergotamine

  (ergot alkaloids)

• finerenone
• ivabradine
• long-acting barbiturates like phenobarbital

• lurasidone
• naloxegol
• pimozide
• quinidine
• rifabutin
• rifampin
• ritonavir

• sirolimus
• St. John's Wort (herbal supplement)
• tolvaptan
• venetoclax
• voclosporin

Ask your healthcare provider or pharmacist if you are not sure if you are taking any of the medicines listed above.

Do not start taking a new medicine without talking to your healthcare provider or pharmacist.

Before you take Voriconazole for Injection, tell your healthcare provider about all of your medical conditions, including if you:

• have or ever had heart disease, or an abnormal heart rate or rhythm. Your healthcare provider may order a test to check your heart (EKG) before starting Voriconazole for Injection.
• have low potassium levels, low magnesium levels, and low calcium levels. Your healthcare provider may do blood tests before starting and during treatment with Voriconazole for Injection.
• have liver or kidney problems. Your healthcare provider may do blood tests to make sure you can take Voriconazole for Injection.

• are pregnant or plan to become pregnant. Voriconazole for Injection can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Women who can become pregnant should use effective birth control while taking Voriconazole for Injection. Talk to your healthcare provider about birth control methods that may be right for you.

• are breastfeeding or plan to breastfeed. It is not known if Voriconazole for Injection passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Voriconazole for Injection.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Voriconazole for Injection may affect the way other medicines work, and other medicines may affect how Voriconazole for Injection works.

Know what medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

How should I take Voriconazole for Injection?

• Voriconazole for Injection may be prescribed to you as:

  • Voriconazole for Injection (intravenous infusion)
• Voriconazole for Injection will be given to you by a healthcare provider over 1 to 3 hours.
• If you take too much Voriconazole for Injection, call your healthcare provider or go to the nearest hospital emergency room.

What should I avoid while taking Voriconazole for Injection?

• You should not drive at night while taking Voriconazole for Injection. Voriconazole for Injection can cause changes in your vision such as blurring or sensitivity to light.
• Do not drive or operate machinery, or do other dangerous activities until you know how Voriconazole for Injection affects you.
• Avoid direct sunlight. Voriconazole for Injection can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get a severe sunburn. Use sunscreen and wear a hat and clothes that cover your skin if you have to be in sunlight. Talk to your healthcare provider if you get sunburn.

What are the possible side effects of Voriconazole for Injection?

Voriconazole for Injection may cause serious side effects including:

• liver problems. Symptoms of liver problems may include:

• itchy skin
• flu-like symptoms

• yellowing of your eyes
• nausea or vomiting

• feeling very tired

• serious heart problems. Voriconazole for Injection may cause changes in your heart rate or rhythm, including your heart stopping (cardiac arrest).
• allergic reactions. Symptoms of an allergic reaction may include:

• fever
• chest tightness
• nausea
• flushing

• sweating
• trouble breathing
• itching

• feels like your heart is beating fast (tachycardia)
• feel faint
• skin rash

• vision changes. Symptoms of vision changes may include:

  • blurred vision
  • changes in the way you see colors

• serious skin reactions. Symptoms of serious skin reactions may include:

  • rash or hives
  • mouth sores
  • blistering or peeling of your skin
  • trouble swallowing or breathing
• sensitivity to light or sun (photosensitivity). Voriconazole for Injection can cause serious photosensitivity. There is an increased chance of skin toxicity while taking Voriconazole for Injection. This can happen with or without taking other medicines like methotrexate. Photosensitivity reactions may also increase your risk of:
• • faster skin aging from the sun
  • skin cancer

Call your healthcare provider right away if you get a new skin rash or your skin rash gets worse.

• kidney problems. Voriconazole for Injection may cause new or worse problems with kidney function, including kidney failure. Your healthcare provider should check your kidney function while you are taking Voriconazole for Injection. Your healthcare provider will decide if you can keep taking Voriconazole for Injection.

• adrenal gland problems:

  • Voriconazole for Injection may cause reduced adrenal function (adrenal insufficiency).

  • Voriconazole for Injection may cause overactive adrenal function (Cushing's syndrome) when voriconazole is used at the same time with corticosteroids.

    Symptoms of adrenal insufficiency include:

• feeling tired
• nausea and vomiting
• abdominal pain

• lack of energy
• feeling dizzy or lightheaded

• weakness
• weight loss

Symptoms of Cushing's syndrome include:

• weight gain
• thinning skin
• excessive hair growth

• fatty hump between the shoulders (buffalo hump) and a rounded face (moon face)
• bruising easily
• excessive sweating

• darkening of the skin on the stomach, thighs, breasts, and arms
• high blood sugar

• inflammation of the pancreas (pancreatitis). Symptoms of pancreatitis may include pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back. The pain may happen with or without vomiting.
• bone problems. Voriconazole for Injection may cause weakening of bones and bone pain. Tell your healthcare provider if you have bone pain.

Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the symptoms listed above.

The most common side effects of Voriconazole for Injection in adults include:

• vision changes
• nausea
• hallucinations (seeing or hearing things that are not there)

• rash
• headache
• abnormal liver function tests
• chills

• vomiting
• fast heart beat (tachycardia)
• fever

The most common side effects of Voriconazole for Injection in children include:

• fever
• diarrhea
• low platelet counts
• abnormal liver function tests
• low blood calcium levels
• low blood phosphate levels
• vision changes
• rash
• stomach pain
• trouble breathing
• dizziness

• high blood pressure
• cough
• low blood pressure
• swelling in the arms and legs
• high blood sugar levels
• headache
• fast heart beat (tachycardia)
• nose bleeds
• low blood potassium levels
• low blood levels of albumin
• kidney problems

• inflammation of mucous membranes

• hallucinations (seeing or hearing

  things that are not there)

• coughing up blood
• constipation
• low blood magnesium levels
• fullness of the stomach area
• vomiting
• nausea
• upper respiratory tract infection

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Voriconazole for Injection.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Voriconazole for Injection?

• Store unreconstituted vials of Voriconazole for Injection at room temperature between 59° to 86°F (15° to 30°C). Do not refrigerate or freeze.
• Safely throw away medicine that is out of date or no longer needed.
• Keep Voriconazole for Injection, as well as all other medicines, out of the reach of children.

General information about the safe and effective use of Voriconazole for Injection.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Voriconazole for Injection for a condition for which it was not prescribed. Do not give Voriconazole for Injection to other people, even if they have the same symptoms that you have. It may harm them.

You can ask your healthcare provider or pharmacist for information about Voriconazole for Injection that is written for health professionals.

What are the ingredients in Voriconazole for Injection?

Active ingredient: voriconazole.

Inactive ingredient: sulfobutyl ether beta-cyclodextrin sodium.

This product's labeling may have been updated. For the most recent prescribing information, please visit www.meithealpharma.com.

For more information, go to www.meithealpharma.com or call 1-844-824-8426.

Mfd. for Meitheal Pharmaceuticals

Chicago, IL 60631 (USA)

©2026 Meitheal Pharmaceuticals Inc.

Mfd. by Nanjing King-Friend Biochemical Pharmaceutical Co., Ltd.

Nanjing, China 210061

Product of India

Revised: May 2026

8F9AAMK-04