Sivextro (Tedizolid phosphate): Uses, Side Effects and Dosage

What is SIVEXTRO?

SIVEXTRO tablet is for adults and for children weighing at least 77 pounds (35 kg) who have a skin infection or an infection in the tissue below the skin. SIVEXTRO is an antibiotic that works by stopping the growth of certain bacteria.

SIVEXTRO tablet is not for use in children weighing less than 77 pounds (35 kg).

Medical Conditions

Tell your healthcare provider if you:

• have diarrhea or have ever had diarrhea while taking antibiotics. Tell your healthcare provider, even if you had diarrhea that occurred up to 2 months after you took the antibiotic.
• are allergic to tedizolid phosphate or any of the ingredients in SIVEXTRO. See the end of this Patient Information for a complete list of ingredients in SIVEXTRO.
• are pregnant or plan to get pregnant, tell your healthcare provider if you become pregnant while taking SIVEXTRO. It is not known if SIVEXTRO will harm your baby while you are pregnant. You and your healthcare provider should decide together if you will take SIVEXTRO.

• are breastfeeding or plan to breastfeed, tell your healthcare provider before you take SIVEXTRO. It is not known if SIVEXTRO passes into your breast milk. You and your healthcare provider should decide together if you will take SIVEXTRO or breastfeed.

• SIVEXTRO can affect the way other medicines work, and other medicines can affect how SIVEXTRO works. Some medicines cannot be taken with SIVEXTRO at all. Your healthcare provider will tell you if it is safe to take SIVEXTRO with other medicines.

• It is especially important to tell your healthcare provider if you take any of the following medicines:

  • Methotrexate (for cancer or rheumatoid arthritis)
  • Topotecan (for cancer)
  • Rosuvastatin (for cholesterol)
  • Depression or anxiety medicines
  • Migraine headache medicines called triptans
  • Prescription pain medicines
• Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal and dietary supplements.
• Know the medicines you take. Keep a list of them and show the list to your healthcare provider and pharmacist when you get a new medicine.

How do I take SIVEXTRO?

• Do not give SIVEXTRO tablets to children weighing less than 77 pounds (35 kg).
• Take SIVEXTRO exactly how your healthcare provider tells you to take it.
• Take 1 SIVEXTRO tablet 1 time each day.
• Take SIVEXTRO for 6 days, at the same time every day.

• Take SIVEXTRO by mouth, with or without food.

• If you miss a dose, take the missed dose as soon as you remember.

  If it is less than 8 hours until your next dose, skip the missed dose and take the next tablet at the time you usually take it.

• Do not take 2 doses of SIVEXTRO at the same time to make up for a missed dose.
• If you are not sure how to take SIVEXTRO, call your healthcare provider or pharmacist.
• Take all 6 tablets to finish your SIVEXTRO, even if you have missed a dose.

If you do not finish your medicine, SIVEXTRO may not work.

You may get sick again and the remaining bacteria may be harder to treat.

What are the possible side effects of SIVEXTRO?

SIVEXTRO may cause serious side effects, including:

• Serotonin syndrome. Taking SIVEXTRO with certain other medicines can cause a potentially life-threatening problem called serotonin syndrome. See “ Are you taking other medicines? ”. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs or symptoms of serotonin syndrome:

• Diarrhea from C-diff (Clostridioides difficile) infection. Call your healthcare provider right away if you get stomach cramps, fever, watery diarrhea, diarrhea that does not go away, or bloody stools. C-diff infection can happen 2 or more months after you have finished your antibacterial medicine.

  C-diff is an infection of your intestines (bowels) that can happen with many antibiotics like SIVEXTRO and may cause mild diarrhea to life-threatening swelling of your intestines (colitis).

Common side effects of SIVEXTRO include:

Some less common side effects are:

Problems with your skin

• itching, red or itchy rash, hives, acne
• hot flushes or feeling like you are blushing or your face, neck or chest is red
• not able to feel something as well
• a tingling or prickling sensation

Problems with your sleep

• hard time sleeping

Problems with your body

• numbness
• facial paralysis

Problems with infections

• vagina that is infected, inflamed, or itchy
• fungal infections of skin, mouth

Problems with your eyes

• eye strain
• blurred or impaired vision
• seeing dots or spots in your eyes

Problems with your heart

• Your heartbeat does not feel normal. It could feel like your heart is beating too fast or pumping harder than usual.

Problems with your vascular system

• high blood pressure

Problems with your blood work

Your healthcare provider may tell you that you have the following while taking SIVEXTRO:

• a low white blood cell count
• anemia (low red blood cells)
• low platelet count, the small cells involved in clotting your blood

Side effects where the frequency is not known:

• bleeding or bruising easily

If you have any side effect that bothers you or does not go away, tell your healthcare provider.

These are not all the possible side effects of SIVEXTRO. For information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store SIVEXTRO?

• Store SIVEXTRO at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep SIVEXTRO and all medicines out of the reach of children.

• Medicines are sometimes prescribed for purposes that are not mentioned here.
• Do not use SIVEXTRO for a condition for which it was not prescribed.

• Call your healthcare provider.
• Call the company that makes SIVEXTRO at 1-800-444-2080.
• Go to the website – www.SIVEXTRO.com.
• You can ask your healthcare provider or pharmacist for information about SIVEXTRO that is written for health professionals.

What are the ingredients in SIVEXTRO?

• The active ingredient: tedizolid phosphate.
• The inactive ingredients: crospovidone, magnesium stearate, mannitol, microcrystalline cellulose, and povidone. Film coating: polyethylene glycol/macrogol, polyvinyl alcohol, talc, titanium dioxide, and yellow iron oxide.

Manuf. for: Merck Sharp & Dohme LLC

Rahway, NJ 07065, USA

SIVEXTRO tablets Manufactured by: Patheon Inc., Whitby, Ontario, L1N 5Z5 Canada

SIVEXTRO for injection Manufactured by: Patheon Italia S.p.A., 03013, Ferentino, FR Italy

For patent information: www.msd.com/research/patent. The trademarks depicted herein are owned by their respective companies.

Copyright © 2017-2026 Merck & Co., Inc., Rahway, NJ, USA, and its affiliates. All rights reserved.

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This Patient Information has been approved by the U.S. Food and Drug Administration Revised: 2/2026