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Nitroglycerin Topical: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
0.1 mg/h, 0.2 mg/h, 0.4 mg/h, 0.6 mg/h
Drug class:
Active ingredient:

Patient information: uses, side effects, how to take - Nitroglycerin Topical

How to use

NITROGLYCERIN

TRANSDERMAL SYSTEM

for the prevention of angina

The Nitroglycerin Transdermal Patch is easy to use – it has a clear peelable liner, and a special adhesive that keeps the patch firmly in place.

Where to place the

Nitroglycerin Transdermal Patch

Select any area of skin on the body, EXCEPT the extremities below the knee or elbow. The chest is the preferred site. The area should be clean, dry, and hairless. If hair is likely to interfere with patch adhesion or removal, it can be clipped but not shaved. Take care to avoid areas with cuts or irritations. Do NOT apply the patch immediately after showering or bathing. It is best to wait until you are certain the skin is completely dry.

How to apply the

Nitroglycerin Transdermal Patch

  • Each Nitroglycerin Transdermal Patch is individually sealed in a protective package. Open the pouch at the tear mark. Carefully remove the patch. The patch is printed with the wording ‘Nitroglycerin’ and the amount of nitroglycerin delivered each hour. The patch is attached to a clear peelable liner. The liner has a slit which divides it into two strips. Hold the patch with the wording facing away from you. The slit should now be facing toward you. Rotate the patch as necessary to place the slit in an up and down position.
  • Bend both sides of the clear peelable liner away from you at the slit.
  • Slowly peel off only one of the strips of the clear liner. Do not touch the exposed sticky side of the patch.
  • Using the remaining strip as a “handle”, apply the exposed sticky side of the patch to the skin. Press the sticky side on the chosen skin site and smooth down.
  • Fold back the unattached side of the patch. Grasp the remaining strip and remove it while applying the remainder of the patch to the skin. Press the patch on the skin and smooth down with the palm of your hand. Once the patch is in place, do not test the adhesion by pulling on it.
  • When Nitroglycerin Transdermal Patch is applied to your body, the nitroglycerin contained in the patch begins to flow from the adhesive surface through your skin at a uniform rate.
  • After applying the patch, wash hands to remove any drug.
  • At the time recommended by your doctor, remove and discard the patch.
  • Place a new patch on a different skin site (following steps 1 through 6) according to your doctor’s instructions.

Please note:

Contact with water, as in bathing, swimming, or showering will not affect the patch. In the unlikely event that a patch falls off, discard it and put a new one on a different skin site.

Precautions:

The most common side effect is headache, which often decreases as therapy is continued, but may require treatment with a mild analgesic. Although uncommon, faintness, flushing, and dizziness may occur, especially when suddenly rising from the recumbent (lying horizontal) position. If these symptoms occur, remove the patch and notify your physician.

Skin irritation may occur. If it persists, consult your physician.

Keep these patches and all drugs out of the reach of children.

Important:

Your doctor may decide to increase or decrease the size of the patch, or prescribe a combination of patches, to suit your particular needs. The dose may vary depending on your individual response to the patch.

This patch is to be used for preventing angina, not for treating an acute attack.

Store at 20° to 25°C (68° to 77°F).

Do not refrigerate.

Do not store outside of the protective package. Apply immediately upon removal from the protective package.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For more information, call Mylan Pharmaceuticals Inc. at 1-877-446-3679 (1-877-4-INFO-RX).

Mylan Pharmaceuticals Inc.

Morgantown, WV 26505 U.S.A.

REVISED NOVEMBER 2014

PL:NTG:R12

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: ANDA 074559 · View the label on DailyMed

Revision date stated in the text: November 2014

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Nitroglycerin Topical

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Nitrate Vasodilator
Active ingredient Nitroglycerin
Dosage form Patch
Route Transdermal
Marketing status listed in the FDA NDC Directory
Company (applicant) MYLAN TECHNOLOGIES
FDA approval ANDA 074559Abbreviated New Drug Application (ANDA) – generic drug Approved August 30, 1996
Therapeutic equivalence (TE) code AB2Codes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Manufacturers 4 labelers list this drug on DailyMed
Packages (NDC)
Package
0.1 mg/h – 14 h in 1 patch / 1 in 1 pouch / 30 in 1 carton NDC 0378-9102-16
0.2 mg/h – 14 h in 1 patch / 1 in 1 pouch / 30 in 1 carton NDC 0378-9104-16
0.4 mg/h – 14 h in 1 patch / 1 in 1 pouch / 30 in 1 carton NDC 0378-9112-16
0.6 mg/h – 14 h in 1 patch / 1 in 1 pouch / 30 in 1 carton NDC 0378-9116-16

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.