Medication-info.com Search Menu

Nitroglycerin Tablet (Nitrostat): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
0.4 mg, 0.3 mg, 0.6 mg
Brand names:
Drug class:
Active ingredient:
Similar drugs:

Source: FDA drug labeling via NLM DailyMed · About this document

Patient information: uses, side effects, how to take - Nitroglycerin Tablet

What are nitroglycerin sublingual tablets?

Nitroglycerinis a type of medicine known as an organic nitrate and is a vasodilating agent. It is used to treat a type of chest pain called angina.

What is Angina?

Angina is a pain or discomfort that keeps coming back when part of your heart does not get enough blood. Angina feels like a pressing or squeezing pain, usually in your chest under the breastbone. Sometimes you can feel it in your shoulders, arms, neck, jaws, or back. Nitroglycerincan relieve this pain.

Who should not use nitroglycerin sublingual tablets?

Do not use nitroglycerinif you are allergic to organic nitrates (like the active ingredient in nitroglycerin sublingual tablets).

You should not take nitroglycerin sublingual tabletsif you have the following conditions:

  • very recent heart attack
  • severe anemia
  • increased pressure in the head

Do not take nitroglycerin sublingual tabletswith drugs for erectile dysfunction, like VIAGRA ®(sildenafil citrate), CIALIS ®(tadalafil), or LEVITRA ®(vardenafil hydrochloride), as this may lead to extreme lowering of your blood pressure .

Do not take nitroglycerin sublingual tabletsif you take medicines called guanylate cyclase stimulators which include riociguat, a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension.

What should I tell my doctor before taking nitroglycerin sublingual tablets?

Before using nitroglycerin sublingual tablets, tell your doctor if:

  • You are taking any medicines that are used to treat angina, heart failure, or an irregular heartbeat.
  • You are taking any medicines that reduce blood pressure.
  • You are taking any diuretics (water pills).
  • You are taking medicines that can cause dry mouth such as tricyclic antidepressants (e.g. amitriptyline, desipramine, doxepin), anticholinergic drugs, or any antimuscarinic drugs (e.g. atropine).
  • You are taking ergotamine or similar drugs for migraine headaches.
  • You are taking aspirin.
  • You are taking any medicines for erectile dysfunction.

  • You are pregnant or plan to become pregnant.

  • You are breastfeeding.

How should I take nitroglycerin sublingual tablets?

  • Do not chew, crush, or swallow nitroglycerin sublingual tablets.
  • You should sit down when taking nitroglycerin sublingual tabletsand use caution when you stand up. This eliminates the possibility of falling due to lightheadedness or dizziness.
  • One tablet should be dissolved under the tongue or in the oral cavity at the first sign of chest pain.
  • The dose may be repeated approximately every 5 minutes, until the chest pain is relieved.
  • If the pain persists after a total of 3 tablets in a 15-minute period, or is different than you typically experience, call your doctor or seek emergency help.
  • Nitroglycerin sublingual tabletsmay be used 5 to 10 minutes prior to activities that might cause chest pain.
  • You may feel a burning or tingling sensation in your mouth when you take nitroglycerin sublingual tablets.

What should I avoid while taking nitroglycerin sublingual tablets?

  • Do not breastfeed. It is not known if nitroglycerinwill pass through your milk.
  • Do not consume alcohol while taking nitroglycerin sublingual tablets, as this can lower your blood pressure.
  • Do not start any new prescription or non-prescription medicines or supplements, unless you check with your doctor first.

What are the possible side effects of nitroglycerin sublingual tablets?

Nitroglycerin sublingual tabletmay cause the following side effects:

  • headache
  • vertigo (a major symptom of balance disorder)
  • dizziness
  • weakness
  • heart palpitations (unusual awareness of the heartbeat)
  • low blood pressure upon rising from a seated position
  • nausea and vomiting
  • sweating
  • paleness
  • fainting
  • flushing (warm or red condition of your skin)
  • other skin reactions that may be severe

Tell your doctor if you are concerned about any side effects you experience. These are not all the possible side effects of nitroglycerin sublingual tablets. For a complete list, ask your doctor or pharmacist.

How do I store nitroglycerin sublingual tablets?

Nitroglycerin sublingual tabletsshould be kept in the original glass container and tightly capped after each use to prevent loss of tablet potency.

Store nitroglycerin sublingual tabletsat room temperature (between 68° and 77°F).

General advice about nitroglycerin sublingual tablets

Sometimes doctors will prescribe a medicine for a condition that is not included in the patient information leaflets. Only use nitroglycerin sublingual tabletsthe way your doctor told you to. Do not give nitroglycerin sublingual tabletsto other people, even if they have the same symptoms you have. It may harm them.

You can ask your pharmacist or doctor for information about nitroglycerin sublingual tablets, or you can visit Advagen Pharma website at www.advagenpharma.com or call at 866-488-0312.

All the brands are trademarks of their respective owners.

Manufactured by:

Rubicon Research Limited

Thane, 421506 India

Distributed by:

Advagen Pharma Ltd

East Windsor, NJ 08520, USA.

Revised: 1/2026

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: ANDA 209779 · View the label on DailyMed

Revision date stated in the text: January 2026

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Nitroglycerin Tablet

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Nitrate Vasodilator
Active ingredient Nitroglycerin
Dosage form Tablet
Route Sublingual
Marketing status listed in the FDA NDC Directory
Company (applicant) RUBICON RESEARCH
FDA approval ANDA 209779Abbreviated New Drug Application (ANDA) – generic drug Approved May 3, 2021
Therapeutic equivalence (TE) code ABCodes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Generics Nitrostat with the same TE code
Manufacturers 13 labelers list this drug on DailyMed
Recalls
  • March 13, 2025: Class II recall: CGMP Deviations
  • March 13, 2025: Class II recall: CGMP Deviations
Packages (NDC)
Package
0.4 mg – 25 in 1 bottle / 4 in 1 carton NDC 72888-139-33
0.4 mg – 100 in 1 bottle / 1 in 1 carton NDC 72888-139-01
0.3 mg – 100 in 1 bottle / 1 in 1 carton NDC 72888-138-01
0.6 mg – 100 in 1 bottle / 1 in 1 carton NDC 72888-140-01

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.