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Neostigmine (Bloxiverz): Uses, Side Effects and Dosage

Status:
Prescription (Rx) Being discontinued since January 12, 2026 Facts
Strength:
1 mg/mL
Brand names:
Active ingredient:

Patient information: uses, side effects, how to take - Neostigmine

INSTRUCTIONS FOR USE

Figure 1: Outer Packaging and Prefilled Syringe

NOTES:

    • Do not introduce any other fluid into the syringe at any time.
    • Do not dilute for IV push.
    • Do not re-sterilize the syringe.
    • Do not use this product on a sterile field.
    • This product is for single dose only.
  1. 1. Inspect the outer packaging (blister pack) to confirm the integrity of the packaging. Do not use if the blister pack or the prefilled syringe has been damaged.
  2. 2.

    Remove the syringe from the outer packaging. (See Figure 2)

    Figure 2

  3. 3. Visually inspect the syringe. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
  4. 4.

    Twist off the syringe tip cap. Do not remove the label around the luer lock collar. (See Figure 3)

    Figure 3

  5. 5. Expel air bubble(s). Adjust the dose (if applicable).
  6. 6. Administer the dose ensuring that pressure is maintained on the plunger rod during the entire administration.
  7. 7. Discard the used syringe into an appropriate receptacle.

For more information concerning this drug, please call Fresenius Kabi USA, LLC at 1-800-551-7176.

To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

U.S. Patents 9,731,082 and 10,661,018

Lake Zurich, IL 60047

www.fresenius-kabi.com/us

451585B

About this document

Source: FDA drug labeling via NLM DailyMed · Application number: NDA 203629 · View the label on DailyMed

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Neostigmine

Rx or OTC
Prescription (Rx)?
  • This drug is available only with a prescription from a licensed healthcare provider.
  • Rx
Drug class Cholinesterase Inhibitor
Active ingredient Neostigmine methylsulfate 1 mg/mL
Dosage form Injection, solution
Route Intravenous
Marketing status listed in the FDA NDC Directory
Company (applicant) FRESENIUS KABI USA
FDA approval NDA 203629New Drug Application (NDA) Approved January 8, 2015
Reference listed drug This is the reference listed drug (RLD) that generics are compared with.
Therapeutic equivalence (TE) code APCodes starting with A mean the FDA rates the drug therapeutically equivalent to its reference drug (Orange Book).
Manufacturers 19 labelers list this drug on DailyMed
Drug shortage
  • Being discontinued since January 12, 2026
Packages (NDC)
Package
1 mg/mL – 3 ml in 1 syringe, glass / 1 in 1 blister pack / 10 in 1 carton NDC 76045-383-13
1 mg/mL – 3 ml in 1 syringe, glass / 1 in 1 blister pack / 10 in 1 carton NDC 76045-214-00

Source: FDA drug labeling via NLM DailyMed, data as of October 31, 2026. FDA data (DailyMed, Orange Book, Drug Shortages, enforcement reports). Not a substitute for the advice of a doctor or pharmacist.